Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives

doi:10.6023/cjoc201610027

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (4): 908-913.DOI: 10.6023/cjoc201610027 Previous Articles Next Articles

ARTICLE

新型碳硫双手性含吡啶结构的邻苯二甲酰胺类化合物的设计、合成与生物活性研究

孟祥德, 周沙, 解永涛, 赵毓, 熊丽霞, 周莎, 李正名

南开大学元素有机化学研究所元素有机化学国家重点实验室天津 30071

收稿日期:2016-10-17 修回日期:2016-12-11 发布日期:2017-01-10
通讯作者: 周莎, 李正名 E-mail:mengsha171657@163.com;nkzml@vip.163.com
基金资助:
国家自然科学青年基金（No.21602118）、天津化学化工协同创新中心资助项目.

Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives

Meng Xiangde, Zhou Sha, Xie Yongtao, Zhao Yu, Xiong Lixia, Zhou Sha, Li Zhengming

State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071

Received:2016-10-17 Revised:2016-12-11 Published:2017-01-10
Contact: 10.6023/cjoc201610027 E-mail:mengsha171657@163.com;nkzml@vip.163.com
Supported by:
Project Supported by the National Natural Science Foundation of China (No. 21602118), and the Collaborative Innovation Center of Chemical Science and Engineering (Tianjin).

1. Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives.PDF(930KB)

Abstract

In order to find efficient, low toxicity, eco-friendly insecticides, novel chiral carbon and sulfur phthalic acid diamide derivatives containing pyridine substitute were designed and synthesized for further studying the structure-activity relationship of dual-chiral sulfilimines and sulfoximines. Their structures were confirmed by NMR and HRMS. The preliminary results of biological evaluation showed that the most compounds exhibited moderate larvicidal activity. These results provide a theoretical basis for the study of the dicarboxamide structures containing sulfiliminyl and sulfoximinyl moieties.

Key words: pyridine, phthalic acid diamides, synthesis, insecticidal activity, dual-chiral

Cite this article

Meng Xiangde, Zhou Sha, Xie Yongtao, Zhao Yu, Xiong Lixia, Zhou Sha, Li Zhengming. Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives[J]. Chin. J. Org. Chem., 2017, 37(4): 908-913.

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新型碳硫双手性含吡啶结构的邻苯二甲酰胺类化合物的设计、合成与生物活性研究

Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives

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