Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group

doi:10.6023/cjoc201708026

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3267-3273.DOI: 10.6023/cjoc201708026 Previous Articles Next Articles

Notes

新型含取代四氮唑环结构的吡唑肟类化合物的合成与生物活性研究

戴红^a, 姚炜^a, 杜显超^a, 王祥龙^a, 吴锦明^a, 陈庆文^a, 李春建^b, 石健^b, 张海军^a

a 南通大学化学化工学院南通 226019;
b 南通大学分析测试中心南通 226019

收稿日期:2017-08-13 修回日期:2017-09-06 发布日期:2017-09-26
通讯作者: 吴锦明, 张海军 E-mail:ntgao2016@163.com;hjzh1893@163.com
基金资助:
国家自然科学基金（No.21372135）、江苏省“六大人才高峰”（No.2013-SWYY-013）和江苏省研究生实践创新计划（No.SJCX17_0640）资助项目.

Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group

Dai Hong^a, Yao Wei^a, Du Xianchao^a, Wang Xianglong^a, Wu Jinming^a, Chen Qingwen^a, Li Chunjian^b, Shi Jian^b, Zhang Haijun^a

a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
b Analysis and Testing Center, Nantong University, Nantong 226019

Received:2017-08-13 Revised:2017-09-06 Published:2017-09-26
Contact: 10.6023/cjoc201708026 E-mail:ntgao2016@163.com;hjzh1893@163.com
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. SJCX17_0640).

1. Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group.PDF(894KB)

Abstract

In order to explore novel pyrazole oxime derivatives with potent biological activities, a series of novel pyrazole oximes carrying tetrazole unit were designed and synthesized by the method of active substructure combination. The structures of the title compounds were confirmed by ¹H NMR,¹³C NMR, and elemental analysis. Preliminary bioassay data showed that some aimed compounds displayed good insecticidal activities. At the concentration of 500 μg/mL, ten compounds exhibited insecticidal activity against Oriental armyworm with 90%~100%, nine compounds had insecticidal activity against Aphis medicaginis with 80%~100%, ten compounds possessed insecticidal activity against Nilaparvata lugens with 80%~100%, and one compound exhibited 80% acaricidal activity against Tetranychus cinnabarinus. When the concentration was reduced to 100 μg/mL, one compound still showed insecticidal activity against Aphis medicaginis with 85%. Additionally, some compounds had certain fungicidal activity, at 200 μg/mL two compounds showed 60%~80% fungicidal activity against Pseudoperonospora cubensis.

Key words: tetrazole, pyrazole oxime, synthesis, biological activity

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Dai Hong, Yao Wei, Du Xianchao, Wang Xianglong, Wu Jinming, Chen Qingwen, Li Chunjian, Shi Jian, Zhang Haijun. Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group[J]. Chin. J. Org. Chem., 2017, 37(12): 3267-3273.

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新型含取代四氮唑环结构的吡唑肟类化合物的合成与生物活性研究

Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group

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