Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction

doi:10.6023/cjoc201709033

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (4): 855-862.DOI: 10.6023/cjoc201709033 Previous Articles Next Articles

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微波促进下三组分反应构建3-取代吲哚衍生物

林伟^a, 胡秀秀^a, 王雅珍^a, 宋帅^a, 张梦烨^b, 史达清^b

a 江苏理工学院化学与环境工程学院常州 213001;
b 苏州大学材料与化学化工学部苏州 215123

收稿日期:2017-09-21 修回日期:2017-11-09 发布日期:2017-12-01
通讯作者: 林伟, 史达清 E-mail:linwei@jsut.edu.cn;dqshi@suda.edu.cn
基金资助:
国家自然科学基金（No.21502074）、江苏省高校自然科学重大研究项目（15KJA150006）和江苏省大学生创新训练（No.201711463010Z）资助项目.

Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction

Lin Wei^a, Hu Xiuxiu^a, Wang Yazhen^a, Song Shuai^a, Zhang Mengye^b, Shi Daqing^b

a School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001;
b College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123

Received:2017-09-21 Revised:2017-11-09 Published:2017-12-01
Contact: 10.6023/cjoc201709033 E-mail:linwei@jsut.edu.cn;dqshi@suda.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21502074), the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 15KJA150006) and the College Students Practice Innovation Training Plan of Jiangsu Province (No. 201711463010Z).

1. Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction.PDF(1551KB)

Abstract

The research of indoles has been one of the most active areas of heterocyclic chemistry. In particular, 3-substituted indole derivatives have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds. In this article, an synthetic procedure for multi-substituted indole derivatives was successfully developed by a three-component reaction of phenylglyoxal monohydrate, aromatic amine and 4-hydroxycoumarin with a catalytic amount of trifluoroacetic acid under microwave irradiation conditions. This method has the advantages of simple operation, readily available raw materials, and high atom utilization.

Key words: indole, synthesis, three-component reaction, microwave

Cite this article

Lin Wei, Hu Xiuxiu, Wang Yazhen, Song Shuai, Zhang Mengye, Shi Daqing. Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction[J]. Chin. J. Org. Chem., 2018, 38(4): 855-862.

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微波促进下三组分反应构建3-取代吲哚衍生物

Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction

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