Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity

doi:10.6023/cjoc201801044

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (7): 1779-1785.DOI: 10.6023/cjoc201801044 Previous Articles Next Articles

Articles

两种具有高弛豫率的双核非离子型磁共振对比剂

孙宏顺^a,b, 李玉龙^b, 蒋蕻^b, 郭成^a, 沈临江^a,c

a 南京工业大学化学与分子工程学院南京 211816;
b 南京科技职业学院江苏省磁共振靶向显像剂工程实验室南京 210048;
c 南京工业大学数理科学学院南京 211816

收稿日期:2018-01-29 修回日期:2018-03-04 发布日期:2018-03-29
通讯作者: 沈临江 E-mail:ljshen@njtech.edu.cn
基金资助:
江苏省高校自然科学基金（No.17KJB320001）、江苏省高校品牌专业建设工程（No.PPZY2015B179）、江苏省高等学校大学生创新创业训练计划（No.201712920001Y）和江苏省青蓝工程资助项目.

Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity

Sun Hongshun^a,b, Li Yulong^b, Jiang Hong^b, Guo Cheng^a, Shen Linjiang^a,c

a College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816;
b Targeted MRI Contrast Agents Laboratory of Jiangsu Province, Nanjing Polytechnic Institute, Nanjing 210048;
c School of Physical and Mathematical Sciences, Nanjing Tech University, Nanjing 211816

Received:2018-01-29 Revised:2018-03-04 Published:2018-03-29
Contact: 10.6023/cjoc201801044 E-mail:ljshen@njtech.edu.cn
Supported by:
Project supported by the Natural Science Foundation in Jiangsu Province (No. 17KJB320001), the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (No. PPZY2015B179), the Training Program of Students Innovation and Entrepreneurship in Jiangsu Province (No. 201712920001Y), and the Qing Lan Project of Jiangsu Province.

1. Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity.PDF(1293KB)

Abstract

Magnetic resonance imaging (MRI) is widely used in diagnostic medicine and soft tissue imaging. Contrast agents (CAs) can improve the specificity of MRI enhancement. Herein, the design, synthesis and relaxivity of two novel binuclear nonionic Gd-based DOTA-hydrazide derived MRI contrast agents, (Gd-DOTAH)₂-DYMB and (Gd-DOTAH)₂-DYMBP are reported. They have improved longitudinal relaxivity values of 11.4 and 11.7 L·mmol^-1·s^-1 per molecule or 5.7 and 5.9 L·mmol^-1·Gd^-1·s^-1 at 0.5 T, respectively, which are higher than that of the mononuclear clinical macrocyclic agent Gd-DOTA. And in vitro MRI studies suggest the potential of these two agents as MRI contrast agents in improving the diagnostic sensitivity and accuracy.

Key words: magnetic resonance imaging (MRI), contrast agents, synthesis, relaxivity, DOTA-hydrazide, Gd-DOTA

Cite this article

Sun Hongshun, Li Yulong, Jiang Hong, Guo Cheng, Shen Linjiang. Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity[J]. Chin. J. Org. Chem., 2018, 38(7): 1779-1785.

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两种具有高弛豫率的双核非离子型磁共振对比剂

Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity

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