Total Synthesis of Pulchrol and Pulchral

doi:10.6023/cjoc201907024

Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2936-2940.DOI: 10.6023/cjoc201907024 Previous Articles Next Articles

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Pulchrol和Pulchral的合成研究

郭冬冬^a, 张武霞^a, 高文梅^a, 郭晓迪^a, 王永强^b^*()

a 山西农业大学文理学院山西太谷 030801
b 西北大学化学与材料科学学院西安 710069

收稿日期:2019-07-17 修回日期:2019-08-20 发布日期:2019-09-05
通讯作者: 王永强 E-mail:wangyq@nwu.edu.cn
基金资助:
国家自然科学基金(31800678);山西省青年基金(201801D221062);山西省青年基金(201801D221063);山西省优秀博士来晋工作奖励(SXYBKY201737);山西省优秀博士来晋工作奖励(SXYBKY201706);山西农业大学科技创新基金(Nos. 2017YJ38);山西农业大学科技创新基金(2017YJ41)

Total Synthesis of Pulchrol and Pulchral

Guo, Dongdong^a, Zhang, Wuxia^a, Gao, Weimei^a, Guo, Xiaodi^a, Wang, Yongqiang^b^*()

a College of Arts and Sciences, Shanxi Agricultural University, Taigu 030801, Shanxi
b Department of Chemistry &Materials Science, Northwest University, Xi'an 710069;

Received:2019-07-17 Revised:2019-08-20 Published:2019-09-05
Contact: Wang, Yongqiang E-mail:wangyq@nwu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China(31800678);the Science and Technology Research Project in ShanXi Province(201801D221062);the Science and Technology Research Project in ShanXi Province(201801D221063);the Shanxi Excellent Doctor Grant Award(SXYBKY201737);the Shanxi Excellent Doctor Grant Award(SXYBKY201706);the Science and Technology Innovation Project of Shanxi Agricultural University(Nos. 2017YJ38);the Science and Technology Innovation Project of Shanxi Agricultural University(2017YJ41)

The total synthesis of natural products pulchrol and pulchral with antiprotozoan activity was reported, starting from the cheap hydroquinone and 4-methylbenzoic acid and using palladium-catalyzed intramolecular decarboxylation coupling reaction of arene carboxylic acids with aryl bromides as the key reaction. This method provides an opportunity for further study of the structure-activity relationship.

Key words: natural product, total synthesis, cross-coupling, pulchrol, pulchral

Cite this article

Guo, Dongdong, Zhang, Wuxia, Gao, Weimei, Guo, Xiaodi, Wang, Yongqiang. Total Synthesis of Pulchrol and Pulchral[J]. Chinese Journal of Organic Chemistry, 2019, 39(10): 2936-2940.

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Pulchrol和Pulchral的合成研究

Total Synthesis of Pulchrol and Pulchral

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