Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Benzotriazolyl Moiety

doi:10.6023/cjoc202008031

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4315-4321.DOI: 10.6023/cjoc202008031 Previous Articles Next Articles

含苯并三氮唑单元的新型吡唑肟衍生物的合成与生物活性

朱玥, 郑丹丹, 缪何一, 钱程, 戴红, 梁凯, 周贝贝, 石玉军, 荀校, 王阳

南通大学化学化工学院南通 226019

收稿日期:2020-08-18 修回日期:2020-09-27 发布日期:2020-10-15
通讯作者: 戴红, 王阳 E-mail:daihong_2015@aliyun.com;wangyang1617@sina.com
基金资助:
国家自然科学基金（Nos.21372135，21802075）、南通市科技计划（No.MS12019060）资助项目.

Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Benzotriazolyl Moiety

Zhu Yue, Zheng Dandan, Miao Heyi, Qian Cheng, Dai Hong, Liang Kai, Zhou Beibei, Shi Yujun, Xun Xiao, Wang Yang

College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Received:2020-08-18 Revised:2020-09-27 Published:2020-10-15
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21372135, 21802075), and the Science and Technology Project Fund of Nantong City (No. MS12019060).

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Abstract

In search of new N-heterocyclic compounds possessing good biological activities, 17 novel pyrazole oxime derivatives were designed and synthesized by introducing benzotriazole moiety into pyrazole oxime skeleton based on fenpyroximate. Their structures were tested by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay data displayed that 3 compounds showed 70%~100% insecticidal activities towards Tetranychus cinnabarinus at 20 μg/mL. 6 compounds possessed 90%~100% mortality rates towards Aphis medicaginis at 20 μg/mL. Moreover, 16 compounds displayed more than 80% insecticidal activities against Mythimna separata (Walker) at 500 μg/mL.

Key words: benzotriazole, pyrazole oxime, synthesis, biological activity

Cite this article

Zhu Yue, Zheng Dandan, Miao Heyi, Qian Cheng, Dai Hong, Liang Kai, Zhou Beibei, Shi Yujun, Xun Xiao, Wang Yang. Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Benzotriazolyl Moiety[J]. Chinese Journal of Organic Chemistry, 2020, 40(12): 4315-4321.

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含苯并三氮唑单元的新型吡唑肟衍生物的合成与生物活性

Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Benzotriazolyl Moiety

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