Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (1): 293-301.DOI: 10.6023/cjoc202105008 Previous Articles Next Articles
ARTICLES
尹丽君, 李超群, 吴晓霞, 徐广森, 李志颖, 沈月毛*()
收稿日期:
2021-05-06
修回日期:
2021-06-06
发布日期:
2021-06-29
通讯作者:
沈月毛
基金资助:
Lijun Yin, Chaoqun Li, Xiaoxia Wu, Guangsen Xu, Zhiying Li, Yuemao Shen()
Received:
2021-05-06
Revised:
2021-06-06
Published:
2021-06-29
Contact:
Yuemao Shen
Supported by:
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Lijun Yin, Chaoqun Li, Xiaoxia Wu, Guangsen Xu, Zhiying Li, Yuemao Shen. Synthesis of (E)-N-(4-Styrene) Acrylamides for DNA Topoisomerase IIα Inhibitors and Antitumor Agents[J]. Chinese Journal of Organic Chemistry, 2022, 42(1): 293-301.
Compd. | Ar | KG1/ (μmol•L–1) | MDA-MB-231/ (μmol•L–1) | Compd. | Ar | KG1/ (μmol•L–1) | MDA-MB-231/ (μmol•L–1) |
---|---|---|---|---|---|---|---|
A1 | o-Tolyl | 8.3 | 1.87 | B2 | m-Tolyl | 3.18 | 7.61 |
A2 | m-Tolyl | >10 | >10 | B3 | p-Tolyl | 7.92 | 6.52 |
A3 | p-Tolyl | >10 | >10 | B4 | 2-Hydroxyphenyl | 1.6 | 0.82 |
A4 | 2-Methoxyphenyl | >10 | 3.91 | B5 | 3-Hydroxyphenyl | 3.03 | 1.53 |
A5 | 3-Methoxyphenyl | >10 | 3.72 | B6 | 4-Hydroxyphenyl | 6.36 | 2.17 |
A6 | 4-Methoxyphenyl | >10 | >10 | B7 | 3-Nitrophenyl | 2.58 | 3.49 |
A7 | 3-Nitrophenyl | >10 | >10 | B8 | Thiophen-2-yl | 1.59 | 4.02 |
A8 | Thiophen-2-yl | >10 | >10 | B9 | Thiophen-3-yl | 0.5 | 1.88 |
A9 | Thiophen-3-yl | >10 | 2.7 | CL-2 | 1.35 | 2.90 | |
B1 | o-Tolyl | 0.43 | 3.56 | VP16 | 0.91 | 6.62 |
Compd. | Ar | KG1/ (μmol•L–1) | MDA-MB-231/ (μmol•L–1) | Compd. | Ar | KG1/ (μmol•L–1) | MDA-MB-231/ (μmol•L–1) |
---|---|---|---|---|---|---|---|
A1 | o-Tolyl | 8.3 | 1.87 | B2 | m-Tolyl | 3.18 | 7.61 |
A2 | m-Tolyl | >10 | >10 | B3 | p-Tolyl | 7.92 | 6.52 |
A3 | p-Tolyl | >10 | >10 | B4 | 2-Hydroxyphenyl | 1.6 | 0.82 |
A4 | 2-Methoxyphenyl | >10 | 3.91 | B5 | 3-Hydroxyphenyl | 3.03 | 1.53 |
A5 | 3-Methoxyphenyl | >10 | 3.72 | B6 | 4-Hydroxyphenyl | 6.36 | 2.17 |
A6 | 4-Methoxyphenyl | >10 | >10 | B7 | 3-Nitrophenyl | 2.58 | 3.49 |
A7 | 3-Nitrophenyl | >10 | >10 | B8 | Thiophen-2-yl | 1.59 | 4.02 |
A8 | Thiophen-2-yl | >10 | >10 | B9 | Thiophen-3-yl | 0.5 | 1.88 |
A9 | Thiophen-3-yl | >10 | 2.7 | CL-2 | 1.35 | 2.90 | |
B1 | o-Tolyl | 0.43 | 3.56 | VP16 | 0.91 | 6.62 |
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