Synthesis of Triarylmethane Derivatives by Baeyer Condensation in a Deep Eutectic Solvent

doi:10.6023/cjoc202106003

Abstract

Triarylmethane derivatives and their syntheses are of great interest owing to their broad applicability in areas from textiles to medicine. In this study, the green solvent [ChCl][ZnCl₂] synergistically promoted Baeyer condensation between benzaldehyde and N-substituted aniline to efficiently synthesize triarylmethane derivatives with high para-selectivity. The employed deep eutectic solvent acted as both a catalyst and green reaction medium for the reaction. Moreover, the deep eutectic solvent was reused several times in this procedure without significant loss of activity.

Key words: triarylmethane derivatives, deep eutectic solvents, Baeyer condensation, green chemistry

Cite this article

Zhanggao Le, Zhiyu Hu, Xuehua Chen, Liyuan Yan, Yishuai Liu, Zongbo Xie. Synthesis of Triarylmethane Derivatives by Baeyer Condensation in a Deep Eutectic Solvent[J]. Chinese Journal of Organic Chemistry, 2021, 41(11): 4415-4420.

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深共融溶剂中Baeyer缩合反应合成三芳基甲烷衍生物