Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (6): 1609-1625.DOI: 10.6023/cjoc202201047 Previous Articles     Next Articles

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可见光不对称催化合成手性氮杂芳烃衍生物

尹艳丽a,c, 赵筱薇b,*(), 江智勇b,c,*()   

  1. a 河南工业大学生物工程学院 郑州 450001
    b 河南大学河南省手性化学国际联合基地 河南开封 475004
    b 河南师范大学化学化工学院 河南新乡 453007
  • 收稿日期:2022-01-28 修回日期:2022-02-21 发布日期:2022-03-03
  • 通讯作者: 赵筱薇, 江智勇
  • 基金资助:
    国家自然科学基金(22171072); 国家自然科学基金(21925103); 中国博士后科学基金(2020M680098)

Asymmetric Photocatalytic Synthesis of Enantioenriched Azaarene Derivatives

Yanli Yina,c, Xiaowei Zhaob(), Zhiyong Jiangb,c()   

  1. a College of Bioengineering, Henan University of Technology, Zhengzhou 450001
    b International Scientific and Technological Cooperation Base of Chiral Chemistry, Henan University, Kaifeng, Henan 475004
    b School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007
  • Received:2022-01-28 Revised:2022-02-21 Published:2022-03-03
  • Contact: Xiaowei Zhao, Zhiyong Jiang
  • Supported by:
    National Natural Science Foundation of China(22171072); National Natural Science Foundation of China(21925103); China Postdoctoral Science Foundation(2020M680098)

The importance of azaarene derivatives in many arenas, especially pharmaceutical and material industry, has attracted increasing attention of chemists to develop highly efficient synthetic methods. To date, functionalization of commercially available azaarenes and their simple derivatives as feedstocks by exploiting the electronic properties of azaarenes to trigger transformations has been appreciated as a powerful tool. Among them, due to the advantages of mild reaction conditions, good functional group tolerance and diverse reaction types, the methods via visible light-driven photocatalysis have been extensively explored. Notably, a number of asymmetric manifolds towards the synthesis of enantioenriched imine-containing azaarene derivatives have been established with satisfactory results. The advances of this important area are summarized and discussed according to the relative positions of the formed stereocenters to azaarenes.

Key words: visible light, asymmetric photocatalysis, radical addition, protonation, azaarene