Synthesis and Biological Activity of 1-[2-(2,4-Dichlorophenoxyl)acetyl]- 5-amino-1H-pyrazole Derivatives

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (7): 797-801. Previous Articles Next Articles

1-[2-(2,4-二氯苯氧)乙酰基]-5-氨基-1H-吡唑衍生物的合成与生物活性

王宏青^a,b, 刘惠^a, 刘钊杰^*,a

^a华中师范大学有机合成研究所武汉 430079
^b南华大学化学化工学院衡阳 421001

收稿日期:2003-09-15 修回日期:2003-11-25 接受日期:2004-02-12 发布日期:2022-09-20
通讯作者: ^*E-mail: zhjliu@ccnu.edu.cn
基金资助:
科技部国家“九五”重点科技攻关(No. 97-563-02-05)资助项目

Synthesis and Biological Activity of 1-[2-(2,4-Dichlorophenoxyl)acetyl]- 5-amino-1H-pyrazole Derivatives

WANG, Hong-Qing^a,b, LIU, Hui^a, LIU, Zhao-Jie^*,a

^a Institute of Organic Synthesis, Central China Normal University, Wuhan 430079
^b College of Chemistry & Chemical Engineering, Nanhua University, Hengyang 421001

Received:2003-09-15 Revised:2003-11-25 Accepted:2004-02-12 Published:2022-09-20

Abstract

In an attempt to discover novel compounds with high activity and low toxicity, a series of new 1-[2-(2,4-dichlorophenoxyl)acetyl]-5-amino-1H-pyrazole derivatives 3a～3j and 4a～4d have beendesigned and synthesized by the reaction of 2,4-dichlorophenoxylacetyl chloridewith 5-amino-1H-pyrazole. The structures of all new compounds were confirmed by elemental analyses, ¹H NMR, IR and MS spectroscopies. The results of preliminary bioassay indicate that compounds 3a～3j and 4a～4d possess high herbicidal activity against the root of rape and barnyard grass.

Key words: 1-[2-(2,4-dichlorophenoxyl)acetyl]pyrazole, synthesis, herbicide

Cite this article

WANG, Hong-Qing, LIU, Hui, LIU, Zhao-Jie. Synthesis and Biological Activity of 1-[2-(2,4-Dichlorophenoxyl)acetyl]- 5-amino-1H-pyrazole Derivatives[J]. Chinese Journal of Organic Chemistry, 2004, 24(7): 797-801.

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1-[2-(2,4-二氯苯氧)乙酰基]-5-氨基-1H-吡唑衍生物的合成与生物活性

Synthesis and Biological Activity of 1-[2-(2,4-Dichlorophenoxyl)acetyl]- 5-amino-1H-pyrazole Derivatives

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