Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (6): 1793-1810.DOI: 10.6023/cjoc202309023 Previous Articles     Next Articles

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水鬼蕉碱Pancratistatin的合成方法研究进展

梁蕾蕾b,†, 姚家灿a,†, 丁凡a, 徐畅a, 刘丹丹a,*()   

  1. a 昆明医科大学药学院暨云南省天然药物药理重点实验室 昆明 650500
    b 昆明医科大学基础医学院 昆明 650500
  • 收稿日期:2023-11-28 修回日期:2024-01-12 发布日期:2024-03-05
  • 作者简介:
    共同第一作者
  • 基金资助:
    国家自然科学基金(2104044); 云南省基础研究计划(202201AS070086); 云南省科技厅-昆明医科大学应用基础研究联合专项(202201AY070001-003); 云南省科技厅-昆明医科大学应用基础研究联合专项(202101AY070001-041); 云南省院士专家工作站(202305AF150054); 云南省天然药物药理重点实验室开放基金(YKLPNP-G2305)

Research Progress on the Synthetic Methods of Pancratistatin

Leilei Liangb,†, Jiacan Yaoa,†, Fan Dinga, Chang Xua, Dandan Liua,*()   

  1. a School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University, Kunming 650500
    b Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500
  • Received:2023-11-28 Revised:2024-01-12 Published:2024-03-05
  • Contact: * liudandan1017@qq.com
  • About author:
    These authors contributed equally to this work.
  • Supported by:
    National Natural Science Foundation of China(2104044); Yunnan Fundamental Research Projects(202201AS070086); Yunnan Provincial Science and Technology Department-Kunming Medical University Applied Basic Research Joint Special Fund Project(202201AY070001-003); Yunnan Provincial Science and Technology Department-Kunming Medical University Applied Basic Research Joint Special Fund Project(202101AY070001-041); Yunnan Academician Expert Workstation(202305AF150054); Open Fund of Yunnan Key Laboratory of Pharmacology for Natural Products(YKLPNP-G2305)

Pancratistatin is a natural alkaloid with prominent antitumor activity. Structurally, pancratistatin has an isocarbostyril core skeleton, fused with a highly oxygenated cyclohexane ring, with six consecutive stereogenic centers. Regioselective introduction of substituted aromatic ring into the core structure, construction of the lactam ring, and control of stereocenters are major challenges in the synthesis of pancratistatin. The preliminary synthetic work of pancratistatin and the research progresses of its total synthesis since 2000 are summarized, and the synthetic strategies and key steps during the total synthesis are illustrated.

Key words: pancratistatin, racemic synthesis, asymmetric synthesis