Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (3): 673-727.DOI: 10.6023/cjoc202402005 Previous Articles     Next Articles

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电化学不对称合成反应的研究进展

高淳, 刘欣, 王明慧, 刘淑贤, 朱婷婷, 张怡康, 郝二军*(), 杨启亮*()   

  1. 河南师范大学化学化工学院 抗病毒性传染病创新药物全国重点实验室 平原实验室 绿色化学介质与反应教育部重点实验室 精细化学品绿色制造河南省协同创新中心 河南新乡 453007
  • 收稿日期:2024-02-03 修回日期:2024-03-02 发布日期:2024-04-02
  • 基金资助:
    国家自然科学基金(22007028); 河南省自然科学基金(232300421126); 河南师范大学科研启动经费(5101039170920); 大学生创新创业训练计划(202310476058); 大学生创新创业训练计划(202310476055)

Advances in Asymmetric Electrochemical Synthesis

Chun Gao, Xin Liu, Minghui Wang, Shuxian Liu, Tingting Zhu, Yikang Zhang, Erjun Hao(), Qiliang Yang()   

  1. State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007
  • Received:2024-02-03 Revised:2024-03-02 Published:2024-04-02
  • Contact: *E-mail: yangqiliang@htu.edu.cn; hej@htu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(22007028); Natural Science Foundation of Henan Province(232300421126); Henan Normal University Initiation Fund(5101039170920); College Students Innovative Entrepreneurial Training Plan Program(202310476058); College Students Innovative Entrepreneurial Training Plan Program(202310476055)

Asymmetric synthesis is one of the most important and valuable frontiers in exploratory research of synthetic organic chemistry. With the renaissance and vigorous development of organic electrochemistry in recent years, combining electrochemical organic synthesis and asymmetric catalytic strategies can be used to expand the reaction types, activation modes, bond formation systems, and substrate adaptability of asymmetric catalysis using the benefits of organic electrochemistry, which brought new opportunities for the asymmetric transformation that is difficult or impossible to be achieved by traditional methods. Thus, the development of novel, efficient, precise and sustainable electrochemical asymmetric catalytic strategies under mild and eco-friendly conditions is of great research significance. Although there are many advantages and key advances in asymmetric electrocatalysis, major challenges remain. Until now, relatively few examples of asymmetric electrochemical transformations with high enantioselectivity have been reported. In recent years, scholars in the field of organic chemistry around the world have carried out a series of original works in the field of asymmetric electro- chemical catalysis, and achieved remarkable results. The theoretical innovation, technical breakthrough, and difficult challenges in asymmetric electrochemical synthesis in recent decades are summarized. Examples of enantioselective electro-organic synthesis using transition metal catalysts, organocatalysts, biological enzyme catalysts, chemically modified chiral electrodes, chiral electrolytes, chiral solvents and chiral auxiliaries are discussed, along with their related reaction machanistic aspects. Finally, perspectives on this cutting-edge area are also briefly discussed.

Key words: organic electrosynthesis, asymmetric catalysis, enantioselectivity, transition-metal catalysis, organocatalysis