Synthesis of γ-Carbolinone Derivatives via Manganese(III)- Promoted Tandem Phosphinoylation/Cyclization of Activated Alkenes with Phosphites

doi:10.6023/cjoc202509023

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锰促进活化烯烃与亚磷酸酯串联磷酰化/环化反应合成γ-咔啉酮衍生物

印丘梅^a, 刘佳乐^a, 邓世强^a, 黄嘉明^a, 蒋洁^a, 唐裕才^a,*

^a湖南文理学院化学与材料工程学院, 电镀废水回用技术湖南省工程研究中心常德 415000

收稿日期:2025-09-19 修回日期:2025-11-04
基金资助:
湖南省教育厅基金项目(No. 23B0650), 湖南文理学院重点项目(No. 24ZZ02)和常德市科技创新指导性项目(No. 2025ZD124)资助.

Synthesis of γ-Carbolinone Derivatives via Manganese(III)- Promoted Tandem Phosphinoylation/Cyclization of Activated Alkenes with Phosphites

Qiumei Yin^a, Jiale Liu^a, Shiqiang Deng^a, Jiaming Huang^a, Jie Jiang^a, Yucai Tang^a,*

^aCollege of Chemistry and Materials Engineering, Hunan Province Engineering Research Center of Electroplating Wastewater Reuse Technology, Hunan University of Arts and Science, Changde 415000

Received:2025-09-19 Revised:2025-11-04
Contact: ^*E-mail: yctang1009@163.com
Supported by:
Project supported by the Scientific Research Foundation of Hunan Provincial Education Department (No. 23B0650), the Key Research Project of Hunan University of Arts and Sciences (No. 24ZZ02) and the Technology Innovation and Development Guidance Program of Chang De (NO. 2025ZD124).

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Abstract

A manganese(III)-promoted tandem phosphinoylation/cyclization of activated alkenes with phosphites to synthesis γ-carbolinone derivatives has been developed. The present method exhibits excellent compatibility with various N-acryloyl-1H-indole-3-carboxamides and phosphites, and is easy to scale up, providing various γ-carbolinone derivatives in moderate to good yields.

Key words: Manganese, alkenes, phosphites, phosphinoylation/cyclization, γ-carbolinone

Cite this article

Qiumei Yin, Jiale Liu, Shiqiang Deng, Jiaming Huang, Jie Jiang, Yucai Tang. Synthesis of γ-Carbolinone Derivatives via Manganese(III)- Promoted Tandem Phosphinoylation/Cyclization of Activated Alkenes with Phosphites[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202509023.

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锰促进活化烯烃与亚磷酸酯串联磷酰化/环化反应合成γ-咔啉酮衍生物

Synthesis of γ-Carbolinone Derivatives via Manganese(III)- Promoted Tandem Phosphinoylation/Cyclization of Activated Alkenes with Phosphites

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