Default Latest Most Read Please wait a minute... REVIEWS Recent Advances in Photoredox/Nickel Dual-Catalyzed Difunctionalization of Alkenes and Alkynes Lei Xu, Fang Wang, Fan Chen, Shengqing Zhu, Lingling Chu Chinese Journal of Organic Chemistry 2022, 42 (1): 1-15. DOI: 10.6023/cjoc202109002 Published: 30 September 2021 Abstract (4270) HTML (137) PDF (1094KB)(3738) Knowledge map The merger of visible-light photoredox catalysis and nickel catalysis makes it possible to forge challenging chemical bonds under mild conditions. Nevertheless, most of these transformations only construct a single carbon-carbon bond or carbon-heteroatom bond in one operation. In recent years, photoredox/nickel dual catalysis has attracted widespread attention in the field of catalytic difunctionalization of alkenes and alkynes. The synergistic cascade mode enables the construction of multiple chemical bonds in one single pot, providing a mild, efficient and selective protocol for the rapid assembly of complex structural motifs. The latest progress in the photoredox/nickel dual-catalyzed difunctionalization reactions of olefins and alkynes is summarized. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Research Progress of Aggregation-Caused Quenching (ACQ) to Aggregation-Induced Emission (AIE) Transformation Based on Organic Small Molecules Sihong Chen, Jiamin Xu, Yuemei Li, Baoru Peng, Lingyu Luo, Huiye Feng, Zhaohua Chen, Zhaoyang Wang Chinese Journal of Organic Chemistry 2022, 42 (6): 1651-1666. DOI: 10.6023/cjoc202201007 Published: 18 February 2022 Abstract (4149) HTML (87) PDF (1351KB)(3190) Knowledge map Most of the traditional organic fluorescent molecules have notorious aggregation-induced quenching (ACQ) effect, which limits their application in many fields. Therefore, how to achieve the transition from ACQ to aggregation-induced emission (AIE) while maintaining the functional properties of traditional conjugated molecules is of great significance. In recent years, many research groups have done a lot of breakthrough works in this field. According to the construction method and structural characteristics of AIE luminogen (AIEgen), the ACQ to AIE transformation strategy can be divided into two types. Based on the restriction of intramolecular motion (RIM) mechanism, the first one is to decorate ACQphore with typical AIEgen (e.g. tetraphenylethene unit). As the second one, some functional units (e.g. triphenylamine and cyanoethylene moiety) are introduced to realize the construction of AIE molecules from zero starting point as the RIM mechanism. In the latter, the construction of other AIEgen systems involving isomerism and excited-state intramolecular proton transfer (ESIPT) mechanisms has also been prominent recently. Thus, according to these classifications, the new progress on the construction strategy of ACQ-to-AIE transformation in the past five years is summarized from the four aspects of AIEgens’ structure, performance, mechanism and application. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Recent Advances in Chemical Protein Modification via Cysteine Changliu Wang, Yongli Zhao, Junfeng Zhao Chinese Journal of Organic Chemistry 2022, 42 (9): 2774-2792. DOI: 10.6023/cjoc202203008 Published: 01 June 2022 Abstract (2506) HTML (109) PDF (1641KB)(2170) Knowledge map Proteins are the most abundant biomolecules in nature and are involved almost in all living processes. Chemical modification of proteins is an efficient strategy to mediate and study the physical and chemical properties and biological functionalities of proteins. Most protein chemical modifications are based on the bioorthogonal reactivities of the side chain functional groups of certain amino acid residues. Among 20 proteinogenic amino acids, cysteine has become the best choice for chemical protein modification, owning to its relative low abundance in proteins, the unique nucleophilicity and low redox potential of its mercaptan group. The recent advances in chemical protein modification via cysteine are comprehensively reviewed and the challenges and applications for future development are discussed. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Pd-Catalyzed Isomerization of Alkenes Hong-Chao Chen, Yichen Wu, Yang Yu, Peng Wang Chinese Journal of Organic Chemistry 2022, 42 (3): 742-757. DOI: 10.6023/cjoc202109045 Published: 17 November 2021 Abstract (2488) HTML (71) PDF (1005KB)(1800) Knowledge map Starting from commercially available simple olefins, alkene isomerization could realize the efficient construction of multi-substituted alkenes, which might be difficult to access with other synthetic methods, in an atom-economic manner via the stereoselective or positional-selective modulation of the carbon-carbon double bonds. The palladium catalyzed stereoselective (Z/E) and the positional selective isomerization reactions of alkenes are summarized. The mechanistic perspectives, and their synthetic applications in the synthesis of drug molecules and natural products are discussed in detail. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Progress in the Synthesis of Boron Dipyrromethene (BODIPY) Fluorescent Dyes Bin-Kai Liu, Kun-Xu Teng, Li-Ya Niu, Qing-Zheng Yang Chinese Journal of Organic Chemistry 2022, 42 (5): 1265-1285. DOI: 10.6023/cjoc202111001 Published: 18 February 2022 Abstract (2281) HTML (97) PDF (1412KB)(1905) Knowledge map Boron dipyrromethene (BODIPY) dyes are widely used in the fields of life sciences, chemical analysis and optoelectronic materials due to its excellent photophysical properties, favorable biocompatibility, facile synthesis and modification etc. The synthesis and derivative strategies of BODIPY provide the basis for its wide application and have attracted great attention from researchers. In this review, the modification strategies for different reaction positions of BODIPY have been discussed, and Pd-catalyzed cross-coupling reactions and oxidative coupling reactions about BODIPY are discussed individually. Finallly, the development of this field is prospected. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Methods and Application of Absolute Configuration Assignment for Chiral Compounds Rui Ge, Yuanyuan Zhu, Haifeng Wang, Shuangxi Gu Chinese Journal of Organic Chemistry 2022, 42 (2): 424-433. DOI: 10.6023/cjoc202108047 Abstract (1827) HTML (37) PDF (1247KB)(1327) Knowledge map The absolute configuration (AC) assignment of chiral molecules is crucial to the research and application of chiral chemistry. In recent years, various methods for the AC determination for chiral compound fall mainly into three categories according to their principles. The first is the nuclear magnetic resonance (NMR)-based method for determining the AC of chiral compound by exciting the nucleus of the chiral compound in the chiral environment, including the NMR-based method using aromatic ring diamagnetic shielding effect and the NMR method using sugar shift effect. The second is X-ray diffraction (XRD) methods based on atomic resonance scattering, including single crystal and powder XRD. The third is based on the enantiomer refraction and absorption of polarized light, including optical rotation spectroscopy, electronic circular dichroism, vibration circular dichroism and vibration Raman spectroscopy. In addition, other methods such as enzyme-based and homobenzotetramisole (HBTM)-based methods are supplementary. Based on our research experiences in chiral fluorescent recognition and chiral drugs, the principles and application of these methods, aiming to afford beneficial references for chiral chemists and related workers are reviewed. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Recent Advances in the Synthesis of Ynamides Yongli Zhao, Yongliang Tu, Mingzhong Cai, Junfeng Zhao Chinese Journal of Organic Chemistry 2022, 42 (1): 85-99. DOI: 10.6023/cjoc202107051 Published: 08 September 2021 Abstract (1734) HTML (63) PDF (891KB)(1413) Knowledge map Ynamides are a class of special ynamines bearing an electron-withdrawing group on the nitrogen atom. The electron-withdrawing group endows ynamides an optimal balance between the stability and activity, and thus enabling ynamides to be versatile synthons widely used in organic synthetic chemistry. The ynamide chemistry has witnessed a rapid development over the past two decades. As a consequence, its synthetic methods have attracted widespread attention. In this context, the recent advances in the synthesis of ynamides are reviewed herein. According to the structure of the main starting materials, the contents are classified as the synthesis with haloenamides, alkynes or its derivatives, and dihalo-substituted alkenes. The representative mechanisms are also discussed. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Recent Advances for the Construction of Seven-Membered Ring Catalyzed by N-Heterocyclic Carbenes Ting Yao, Jiayan Li, Jiaming Wang, Changgui Zhao Chinese Journal of Organic Chemistry 2022, 42 (4): 925-944. DOI: 10.6023/cjoc202109020 Published: 02 December 2021 Abstract (1608) HTML (86) PDF (860KB)(1445) Knowledge map The seven-membered rings represent an important structural motif and have found wide presence in natural products, biologically active molecules and drugs. In contrast to the five- and six-membered rings, the construction of seven- membered ring remains challenging. Thus, the developing efficient strategies for the synthesis of seven-membered rings is very desirable. N-Heterocyclic carbene (NHC) organocatalysis has been recognized as a powerful and unique tool for the quick construction of complex molecular architectures. Nevertheless, whereas significant advances have been made using NHC as catalysis. However, most of these works concentrated on the assembly of five or six-membered rings. This review highlights the developments and new advances for the construction of seven-membered rings catalyzed by NHC. The aim of this review is to provide an overview of this area and inspire synthetic chemists to develop more efficient and novel strategies for the construction of seven-membered rings. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Recent Advances in Visible-Light-Induced Decarboxylative Coupling Reactions of α-Amino Acid Derivatives Jiayu Hu, Zhiqiang Zhu, Zongbo Xie, Zhanggao Le Chinese Journal of Organic Chemistry 2022, 42 (4): 978-1001. DOI: 10.6023/cjoc202110020 Published: 15 December 2021 Abstract (1256) HTML (57) PDF (1513KB)(1586) Knowledge map Amino acids are an important class of biomass raw materials, which are widely used as starting materials to synthetize bioactive molecules, drugs and functional materials, and are also useful as organic catalysts or metal ligands for asymmetric synthesis. Visible-light-induced organic transformation has attracted enormous interest due to its intrinsic characteristics of sustainability and green chemistry. The use of visible-light to promote decarboxylative coupling of α-amino acids to construct various nitrogen-containing compounds has been considered as an attractive synthetic strategy. This review highlights the recent progress in photocatalytic decarboxylative coupling reactions of α-amino acid derivatives with various partners. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Progresses in Reactive Fluorescent Probes with Fused Aggregation- Induced Emission (AIE) and Excited State Intramolecular Proton Transfer (ESIPT) Structures Yuetian Guo, Yongxin Pan, Lijun Tang Chinese Journal of Organic Chemistry 2022, 42 (6): 1640-1650. DOI: 10.6023/cjoc202112009 Published: 18 February 2022 Abstract (1132) HTML (54) PDF (669KB)(1202) Knowledge map Reactive fluorescent probes with the features of excited state intramolecular proton transfer (ESIPT) and aggregation-induced emission (AIE) have been widely used in the detection of various anions, metal cations and biomolecules in recent years, because they have some advantages including good biocompatibility, good sensing performance, a large Stokes shift, and as well high fluorescence quantum efficiency. The progress in reactive fluorescent probes that are structural simple and have the combined structures of AIE and ESIPT is briefly summarized, and the probes are divided into several types such as benzothiazole, salicylaldehyde Schiff base, hydrazine dihydrazone, chalcone fluorophore, etc. The related researches are discussed and prospected. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Research Progress on the Synthesis of Quercetin Derivatives Yajun Mao, Xiangmin Shao, Yangjie Li, Ruimei Cao, Yali Feng, Guangyu Zhai Chinese Journal of Organic Chemistry 2022, 42 (11): 3588-3605. DOI: 10.6023/cjoc202203016 Published: 05 July 2022 Abstract (1058) HTML (47) PDF (1155KB)(1539) Knowledge map Quercetin, as a natural antioxidant, is mainly found in vegetables, fruits and other plants. It can regulate many intracellular and extracellular signaling pathways related to disease progression. It can be anti-inflammatory, antiviral, anticancer, prevention and treatment of cardiovascular and cerebrovascular diseases, thus has a wide range of pharmacological activities. Due to the structural characteristics of quercetin, its low bioavailability limits its clinical application. However, the low molecular mass and easily modifiable chemical groups of quercetin make it attractive for drug development. Therefore, researchers have designed and synthesized new quercetin derivatives through various methods to improve its unfavorable factors. Many quercetin derivatives with excellent properties, good solubility, high bioavailability, stable metabolism, low toxicity and significant biological activity have been synthesized. The recent progress in the synthesis of quercetin derivatives and their biological activities is reviewed, providing a reference for the further development of quercetin derivatives. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Research Progress of Photoelectric Co-catalysis Yingjie Liu, Zhichuan Wang, Jianping Meng, Chen Li, Kai Sun Chinese Journal of Organic Chemistry 2022, 42 (1): 100-110. DOI: 10.6023/cjoc202106051 Published: 03 September 2021 Abstract (1052) HTML (41) PDF (776KB)(1746) Knowledge map Photochemical and electrochemical reactions, which are mild and green, have been widely used in organic synthesis in recent years. To push the limits of both synthetic technologies, organic chemists have focused on using these two strategies to promote organic transformation in a single reaction system. A series of photoelectrochemical strategies have been developed, and the main one at present is electrochemically mediated photoredox catalysis. In addition, photoexcitation-assisted electroredox strategies have also gradually shown their potential in organic synthesis. These strategies realize the complementary advantages and disadvantages of photochemistry and electrochemistry, and can solve the problems that can not be solved by a single synthetic technology, such as removing oxidizing reducing agents that complicate the reaction, generating intermediates with high activity under mild conditions, and so on. In this paper, the research progress of photoelectrochemical strategies is summarized according to the existing photoelectric catalysis reactions, and the possible mechanism of some reactions is discussed. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Research Progress of Antiviral Drug Targeting the Main Protease of SARS-CoV-2 Chunxia Wang, Xiaodong Hu, Bin Xu, Chunyang Cao Chinese Journal of Organic Chemistry 2022, 42 (7): 1974-1999. DOI: 10.6023/cjoc202202011 Published: 15 April 2022 Abstract (963) HTML (45) PDF (14807KB)(863) Knowledge map The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 in late 2019 posed a serious threat to the world population. Some effective vaccines are currently approved and widely used, but the long-term efficacy and safety of this intervention is controversial given the highly mutagenic nature of the coronavirus. In addition, some antiviral drugs show better effects, but their safety and universality have not been supported by more data. Coronavirus main protease (3CLpro) is a special cysteine protease in the coronavirus family, responsible for processing viral polyproteins to produce yield mature non-structural proteins, which play an important role in the life cycle of coronaviruses and are highly conserved, and therefor is considered as a prominent target for antiviral drug. Strucure studies provide valuable insight into the function of this protease and structural basis of rational inhibitor design. This paper reviews the structure of SARS-CoV-2 3CLpro and the research progress of bright spot inhibitors targeting 3CLpro so far, and introduces binding mode and the structure-activity relationships of inhibitors and 3CLpro in detail. Additionally, we broadly examine available antiviral activity, ADMET and animal tests of these inhibitors. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Research Progress of Chitosan Supported Copper Catalyst in Organic Reactions Yaoyao Zhang, Lijie Zhou, Biao Han, Weishuang Li, Bojie Li, Lei Zhu Chinese Journal of Organic Chemistry 2022, 42 (1): 33-53. DOI: 10.6023/cjoc202107066 Published: 27 September 2021 Abstract (918) HTML (43) PDF (5608KB)(1036) Knowledge map Chitosan is obtained by deacetylation of chitin and is a kind of abundant renewable biomass resource. The molecular structure of chitosan contains a large number of hydroxyl and amino groups, which have strong bonding ability with metal nanoparticles or metal ions. Thus it has been widely used to support various metal particles for the preparation of catalysts. In recent years, chitosan supported copper catalyst has been successfully applied in various types of organic reactions. It has the advantages of high reactivity, good selectivity, easy separation, and can also be reused for many times, which reduces the reaction cost and improves the actual industrial application value. Therefore, based on the preparation of different types of chitosan supported copper catalysts, various types of organic reactions are reviewed, mainly involving the constructions of C—C bond and C—X bond, click chemistry and oxidation/reduction reactions. It will promote the application of chitosan and its derivatives-supported catalysts in the future. Fig. & Tab. | Reference | Related Articles | Metrics REVIEWS Recent Progress in Ambipolar Organic Field-Effect Transistors Based on Organic Semiconductor Bilayer Min Li, Aifeng Lv Chinese Journal of Organic Chemistry 2022, 42 (1): 54-66. DOI: 10.6023/cjoc202107016 Published: 08 September 2021 Abstract (875) HTML (47) PDF (4123KB)(1247) Knowledge map Complementary circuits made of ambipolar organic field-effect transistors (OFETs) have the advantages of low signal to noise ratio, low operation voltage, low power consumption, and so on. Up to now, only a few ambipolar organic semiconductors with balanced hole and electron mobilities have been reported, which is one of the key requirements for high performance complementary circuits. There are thousands of high performance unipolar organic semiconductors. The conducting channels based on both an n-type and a p-type organic semiconductors, which have matched mobilities, will be an effective way to build a high performance ambipolar OFETs. In this review, the key requirements, the electrical properties, and factors correlating with the performance of ambipolar OFETs based on organic bilayer are reported. Fig. & Tab. | Reference | Related Articles | Metrics ARTICLES Density Functional Theory Study on the Mechanism of Organophosphine-Catalyzed [4+2] Cycloaddition Reaction Zheng Li, Yingchun Gu, Dazhen Xu, Xuening Fei, Lei Zhang Chinese Journal of Organic Chemistry 2022, 42 (3): 830-837. DOI: 10.6023/cjoc202109022 Published: 17 November 2021 Abstract (817) HTML (24) PDF (1068KB)(466) Knowledge map Organophosphine-catalyzed cycloaddition reaction provides an efficient method for the construction of valuable heterocycles. In this article, density functional theory calculations were performed on the mechanism of a phosphine-catalyzed [4+2] cycloaddition between conjugated dienes and enones reported recently. The overall reaction consisted of four sequential processes, namely the formation of the zwitterionic intermediate, intermolecular nucleophilic addition, intramolecular cyclization, and removal of the organophosphine. The activation free-energy barrier was estimated to be 84.4 kJ/mol, and the overall free-energy change was computed to be –18.8 kJ/mol. For the asymmetric variant of the reaction, the predicted enantioselectivity results were consistent with experimental findings, and what’s more, a distortional strain model was proposed to understand the observed enantioselectivity. Lastly, the substituent effects concerning the diene substrate were explored, which revealed that an ester group on the C(2) position would exert a much stronger influent on the reactivity than that on the C(1) position. The conclusions drawn in this work can help organic chemists to optimize experimental conditions and design new reactions. Fig. & Tab. | Reference | Supporting Info. | Related Articles | Metrics ARTICLES Synthesis and Study of Performance for An Enhanced Formaldehyde Fluorescent Probe Huixu Lu, Yonghe Tang, Hongmei Zhou, Weiying Lin Chinese Journal of Organic Chemistry 2022, 42 (4): 1163-1169. DOI: 10.6023/cjoc202110012 Published: 22 December 2021 Abstract (762) HTML (35) PDF (2551KB)(829) Knowledge map Formaldehyde (FA) is closely related to the environment and people’s health. For example, when FA is absorbed by the human body after exposure to the environment, it will cause discomfort such as headache and throat inflammation, or damage the vital organs of the human body and then cause diseases such as leukemia and Alzheimer's disease. For the rapid detection of FA in the environment, a fluorescent enhanced FA probe HSU-FA was developed. The probe uses naphthalimide dye as the fluorescent platform and hydrazine group as the site of FA recognition. The FA recognition effect is achieved by the condensation reaction between hydrazine group and carbonyl group condensation to form hydrazone. According to the optimization of test conditions, under the test condition of 30% acetic acid content, the probe HSU-FA has the best identification effect on FA. According to the UV-vis absorption spectrum, the absorption spectrum of the probe was significantly enhanced under the action of FA. The fluorescence spectrum test shows that the probe has outstanding recognition ability and response speed to FA. In addition, the probe has a strong resistance to photobleaching and can be stable in solution. The interaction between the probe and FA in solution showed different fluorescence intensities, showing a strong concentration dependence. More importantly, the rapid detection of FA in the environment by using the FA detection card prepared from non-woven fabrics was realized. Fig. & Tab. | Reference | Supporting Info. | Related Articles | Metrics REVIEWS Research Progress of Fluorescence Probes Constructed by Cyclodextrin Derivatives and Inclusion Complexes Yuqing He, Lin Chen, Ruili He, Keli Zhong, Lijun Tang Chinese Journal of Organic Chemistry 2022, 42 (3): 785-795. DOI: 10.6023/cjoc202108024 Published: 10 November 2021 Abstract (711) HTML (38) PDF (5823KB)(1219) Knowledge map Cyclodextrins are a kind of the most important host compounds in supramolecular chemistry, and have been widely used in many fields such as drug release, chemical sensing, enantiomer separation and new materials. Because cyclodextrins have a barrel-shaped structure that is hydrophilic on the outside and hydrophobic on the inside, receptors with recognition functions or fluorescent dyes can be inserted into the cavity of cyclodextrins, which can realize the recognition of target molecules by chelation or displacement. Therefore, construction of fluorescent probes based on cyclodextrins derivatives and inclusion complexes has been received great attention. In this paper, the applications of fluorescent probes that designed and synthesized based on cyclodextrins in the detection of metal ions, anions and molecules are summarized, the recognition performance and mechanisms are described, and it is expected to provide theoretical basis for the application of cyclodextrin derivatives and inclusion complexes in the field of fluorescence detection. Fig. & Tab. | Reference | Related Articles | Metrics Advances in Aggregation-Induced Emission Molecules Based on Organic Photochromism Wei Ding, Bowen Cheng, Meng Wang, Qingyu Dou, Siying Li, Peng Zhang, Qianfu Luo Chinese Journal of Organic Chemistry 2022, 42 (2): 363-383. DOI: 10.6023/cjoc202108046 Abstract (679) HTML (30) PDF (995KB)(678) Knowledge map In recent years, organic aggregation-induced emission (AIE) materials have effectively overcome the main shortcomings of traditional fluorescent materials in aggregation-caused quenching (ACQ) in solid or aggregate state, and have been widely studied and applied in cell imaging, biological probes, optical devices, anti-counterfeiting materials, etc. However, unifunctional AIE materials can’t meet the advancement of science and technology, and the increasing demands for material life. In order to expand the application range of AIE materials, the study of AIE molecules combined with multifunctional groups has further become one of the current focused topics in the field of materials. Multifunctional molecules with both photochromic and AIE properties have received extensive attention due to their promising performances in reversible control and multiple photoresponses upon external stimuli and good control properties. Based on the different isomerization mechanisms of the photochromic units in the multifunctional molecules, and combined with the research practice of our group in this topic, this presentation briefly reviews the main advances and application of AIE molecules based on the different photochromic functional units since the 21st century. It also looks forward to its future development, hoping to provide some reference and thinking for the research in this field. Fig. & Tab. | Reference | Related Articles | Metrics ARTICLES Homogeneous Catalytic Hydrogenation of Dimethyl Malonate into 1,3-Propanediol Xiaolong Fang, Bin Li, Jie Jin, Ning Duan Chinese Journal of Organic Chemistry 2022, 42 (5): 1407-1413. DOI: 10.6023/cjoc202202034 Published: 22 April 2022 Abstract (502) HTML (23) PDF (599KB)(732) Knowledge map Ruthenium complexes [(PPh3)(o-PPh2C6H4NH2)RuCl2]2 (1), (o-PPh2C6H4NHR)2RuCl2 (R=H, 2; Me, 3; Et, 4; CH2Ph, 5) and (o-PPh2C6H4NH2)[(CH2NHR)2]RuCl2 (R=H, 6; Me, 7; Et, 8; iPr, 9) were applied to the catalytic hydrogenation of dimethyl malonate into methyl 3-hydroxypropanoate or 1,3-propanediol. Targeting on the objective of the catalytic hydrogenation efficiency, the influence factors on the dimethyl malonate conversion and methyl 3-hydroxypropanoate or 1,3-propanediol selectivity, such as the structure of the ruthenium complex, the type and amount of the catalyst assistant and solvent, were well investigated. The results revealed that complex 8 resulted in the best catalytic results. Meanwhile, complex 8 could also catalyze the hydrogenation of diesters such as diethyl malonate. Fig. & Tab. | Reference | Supporting Info. | Related Articles | Metrics