化学学报 ›› 2020, Vol. 78 ›› Issue (7): 613-624.DOI: 10.6023/A20040126 上一篇    下一篇

综述

金属有机框架抗菌材料的研究进展

齐野a,b, 任双颂c, 车颖c, 叶俊伟a,b, 宁桂玲a,b   

  1. a 大连理工大学化工学院 精细化工国家重点实验室 大连 116024;
    b 辽宁省硼镁特种功能材料制备与应用技术工程实验室 大连 116024;
    c 大连医科大学附属第一医院 大连 116011
  • 投稿日期:2020-04-28 发布日期:2020-05-30
  • 通讯作者: 叶俊伟, 宁桂玲 E-mail:junweiye@dlut.edu.cn;ninggl@dlut.edu.cn
  • 作者简介:齐野,博士研究生,2017年毕业于大连海事大学,获理学硕士学位.2017年起于大连理工大学化工学院攻读博士学位.主要研究方向为含硼金属有机框架复合材料的结构构筑及其在抗菌、抗癌等生物领域上的应用.
    任双颂,2017年毕业于英国邓迪大学,获理学硕士学位.2018年起就职于大连医科大学附属第一医院.目前主要研究方向为多模态成像引导下恶性肿瘤的微创热消融研究.
    车颖,教授,博士生导师,大连医科大学附属第一医院超声科主任.中国超声医学工程学会委员、超声介入委员会委员及中国抗癌协会肿瘤微创治疗专业委员会委员.目前主要从事良、恶性肿瘤的微创热消融治疗.
    叶俊伟,教授,博士生导师,大连理工大学化工学院副院长.2007年毕业于吉林大学,获博士学位.发表学术论文100余篇,主要从事资源化工和先进功能材料研究.
    宁桂玲,教授,博士生导师,辽宁省硼镁资源化工与新材料工程中心主任.1996年毕业于大连理工大学,获博士学位.在Angew.Chem.,Int.Ed.,J.Am.Chem.Soc.和Chem.Commun.等国际化学期刊发表学术论文200余篇.研究领域主要包括资源化工、能源和生物功能材料.
  • 基金资助:
    项目受国家自然科学基金(Nos.U1808210,U1607101)和中央高校基本科研业务费(No.DUT20LK37)资助.

Research Progress of Metal-Organic Frameworks Based Antibacterial Materials

Qi Yea,b, Ren Shuangsongc, Che Yingc, Ye Junweia,b, Ning Guilinga,b   

  1. a State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024;
    b Engineering Laboratory of Boric and Magnesic Functional Material Preparative and Applied Technology in Liaoning Province, Dalian 116024;
    c The First Affiliated Hospital of Dalian Medical University, Dalian 116011
  • Received:2020-04-28 Published:2020-05-30
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. U1808210, U1607101) and the Fundamental Research Funds for the Central Universities (No. DUT20LK37).

细菌耐药问题已经成为了中国乃至全球的重大公共健康威胁,设计合成新型抗菌材料以减少抗生素依赖成为当前化学化工、材料和生物医学领域中的重要研究课题.金属有机框架(Metal-organic frameworks,MOFs)材料是由有机配体和金属离子或团簇通过配位键自组装形成的多孔晶态材料,在气体吸附与分离、传感和催化等领域都扮演着重要角色.为了寻求更好应对细菌威胁的方式方法,国内外研究者们纷纷构建出不同结构的MOFs材料,并将其应用于抗菌领域.本综述从细菌耐药性的产生和MOFs抗菌机理等方面出发,分类概述了不同金属中心和配体MOFs材料、MOFs包覆金属纳米粒子材料和药物缓释MOFs材料等在抗菌、促进伤口愈合等方面的应用,归纳概括了MOFs材料在抗菌领域应用中仍需解决的科学问题,并对该领域的发展趋势进行了展望.

关键词: 金属有机框架, 抗菌, 机理, 活性氧自由基, 药物输送

With the accelerating process of industrialization and urbanization, as well as the increasing proportion of the elderly in the world's population, we are facing more complex health threats related to bacterial infection. While the vast majority of the bacteria in the body are rendered harmless by the protective effects of the immune system, the continued abuse and misuse of antibiotics has accelerated the spread of antibiotic-resistant bacterial strains and has resulted in substantial new challenges with respect to modern-day antibiotic-based treatments. Therefore, intelligent design of new antibacterial modalities to be used for treating human and livestock diseases is an extremely urgent priority for researchers in the fields of chemistry, chemical engineering, materials and biomedical sciences. Toward this end, the most intriguing of the new developments are metal-organic frameworks (MOFs). MOFs are versatile crystalline porous lattices of organic ligands and metal ion/clusters that formed by self-assembly via coordination bonds. Due to their unique characteristics, including relatively straight forward and simple methods for synthesis, large surface areas, novel and diverse structures, and adjustable porosity, MOFs not only play strong roles with respect to novel methods for gas storage and separation, they may also be utilized in unique applications associated with sensors mechanisms and catalysis. These features contribute to our current understanding of MOFs as promising candidates for the development of pharmaceutical and specifically antibacterial applications. In this review, antibacterial mechanisms, and the development of resistance to current antibiotic strategies are summarized and discussed. The main mechanisms by which bacteria show resistance to antibiotics include altered metabolic pathways, regulation of target sites, and inactivation, modification, and/or reduction in the capacity to accumulate antibacterial drugs. We consider recent progress on the development of MOFs, including the use of specific metal centers and ligands, metal nanoparticles, and drug-encapsulation, all of which have important applications with respect to antibacterial activities, and wound healing. Finally, the challenges and prospects of MOF-based antibacterial materials are discussed, including critical findings, which will help toward the development of the next generation antibacterial MOFs for human use.

Key words: metal-organic framework, antibacterial, mechanism, reactive oxygen species, drug delivery