有机化学 ›› 2017, Vol. 37 ›› Issue (9): 2449-2453.DOI: 10.6023/cjoc201701046 上一篇    下一篇

研究简报

无催化剂、水相合成5,5-(苯基亚甲基)双(2,2-亚丁基-1,3-二噁烷-4,6-二酮)衍生物

张文锋a, 许招会a, 涂缘鸿a, 廖传文bb   

  1. a 江西师范大学化学化工学院 南昌 330022;
    b 江西省人民医院普外科 南昌 330006
  • 收稿日期:2017-01-23 修回日期:2017-04-13 出版日期:2017-09-25 发布日期:2017-04-27
  • 通讯作者: 许招会 E-mail:gotoxzh@163.com
  • 基金资助:

    国家科技攻关计划(No.2001BA323C)和江西省研究生创新基金(No.YC2015-B023)资助项目.

Synthesis of 5,5-(Phenylmethylene)bis(2,2-butylidene-1,3-dioxane-4,6-dione) Derivatives without Catalyst in Water

Zhang Wenfenga, Xu Zhaohuia, Tu Yuanhonga, Liao Chuanwenb   

  1. a Department of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022;
    b Department of General Surgery, Jiangxi Province People's Hospital, Nanchang 330006
  • Received:2017-01-23 Revised:2017-04-13 Online:2017-09-25 Published:2017-04-27
  • Contact: 10.6023/cjoc201701046 E-mail:gotoxzh@163.com
  • Supported by:

    Project supported by the National Science and Technology Project (No. 2001BA323C) and the Graduate Innovation Foundation of Jiangxi Province (No. YC2015-B023).

以芳香醛和2,2-亚丁基-1,3-二噁烷-4,6-二酮为原料,以水为反应介质,无需外加催化剂,通过Knoevenagel缩合与Michael加成的串联反应简单有效地合成了5,5-(苯基亚甲基)双(2,2-亚丁基-1,3-二噁烷-4,6-二酮)衍生物.一系列取代芳香醛被考察,发现该反应具有收率高(63%~83%)、反应温和、操作简单及环境友好等优点.

关键词: 芳香醛, 串联反应, 水相合成, 无催化剂

A new simple and efficient synthesis of 5,5-(phenylmethylene)bis(2,2-butylidene-1,3-dioxane-4,6-dione) derivatives, based on aromatic aldehydes and 2,2-butylidene-1,3-dioxane-4,6-dione, via Tandem reaction of Knoevenagel condensation and Michael addition is described using water as solvent without catalyst. A variety of aromatic aldehydes were engaged in study and afforded respective products in high yields (63%~83%). The reaction has the advantages of mild conditions, simple operation and environmental friendliness.

Key words: aromatic aldehydes, tandem reaction, synthesis in water, catalyst-free