有机化学 ›› 2017, Vol. 37 ›› Issue (9): 2221-2236.DOI: 10.6023/cjoc201703041 上一篇    下一篇

综述与进展

苯并噻唑基荧光探针的设计、合成与应用研究进展

蒋凯a, 曹梁a, 郝志峰b, 陈美燕a, 程洁銮a, 李晓a, 肖萍a, 陈亮a, 汪朝阳a   

  1. a 华南师范大学化学与环境学院 教育部环境理论化学重点实验室 广州 510006;
    b 广东工业大学轻工化工学院 广州 510006
  • 收稿日期:2017-03-24 修回日期:2017-05-14 出版日期:2017-09-25 发布日期:2017-05-25
  • 通讯作者: 汪朝阳, 郝志峰 E-mail:wangzy@scnu.edu.cn;haozhifeng3377@163.com
  • 基金资助:

    广州市科技计划科学研究专项(No.201607010251)、广东省应用型科技研发专项资金(No.2016B090930004)、华南师范大学大创计划(No.20161415)、广东省自然科学基金(No.2014A030313429)及广东省科技计划(No.2017A010103016)资助项目.

Research Progress in Design, Synthesis and Application of Benzothiazole-Based Fluorescent Probes

Jiang Kaia, Cao Lianga, Hao Zhifengb, Chen Meiyana, Cheng Jieluana, Li Xiaoa, Xiao Pinga, Chen Lianga, Wang Zhaoyanga   

  1. a School of Chemistry and Environment, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, South China Normal University, Guangzhou 510006;
    b School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006
  • Received:2017-03-24 Revised:2017-05-14 Online:2017-09-25 Published:2017-05-25
  • Contact: 10.6023/cjoc201703041 E-mail:wangzy@scnu.edu.cn;haozhifeng3377@163.com
  • Supported by:

    Project supported by the Guangzhou Science and Technology Project Scientific Special (No. 201607010251), the Applied Science and Technology Research and Development Special Foundation of Guangdong Province (No. 2016B090930004), the Undergraduates Innovation Project of South China Normal University (No. 20161415), the Natural Science Foundation of Guangdong Province (No. 2014A030313429) and the Guangdong Provincial Science and Technology Project (No. 2017A010103016).

苯并噻唑基团具有特征荧光,且结构中含有N和S杂原子,因而在荧光探针结构中常被视为荧光基团与识别基团,承担荧光信号输出与提供结合位点的重要作用.利用苯并噻唑基团的特点来设计合成性能更佳的荧光探针已逐渐成为荧光探针研究领域中瞩目的焦点.对近几年来报道的苯并噻唑基荧光探针按不同的检测对象分为金属阳离子、阴离子、含硫化合物及其它物种等四大类,综述了其设计、合成、作用机理及其相关检测应用,并展望了其未来的发展趋势.

关键词: 苯并噻唑, 荧光探针, 设计与合成, 检测应用, 进展

Benzothiazole group is of characteristic fluorescence, and each also contains two heteroatoms (N and S). Hence, benzothiazole group is always viewed as fluorophore and recognition moiety in structure of fluorescent probes, playing an essential role on provision of fluorescence signal and binding sites. Recently, utilizing these properties of benzothiazole moiety to design and synthesize better fluorescent probes has gradually become one of focuses in fluorescent detection research. Classifying benzothiazole-based fluorescent probes into four main categories according to different analytes, such as metal cations, anions, sulfur-containing compounds and other species, the design, synthesis, detecting mechanism and relevant application of these probes are reviewed. And their development tendency in the future is prospected.

Key words: benzothiazole, fluorescent probe, design and synthesis, detecting application, progress