有机化学 ›› 2019, Vol. 39 ›› Issue (2): 463-468.DOI: 10.6023/cjoc201807033 上一篇    下一篇

研究论文

通过硝基苯与磺酰氯水相反应直接合成磺酰胺

岳会兰a, 鲍鹏丽b, 王雷雷b, 吕晓霞b, 杨道山b, 王桦b, 魏伟a,b   

  1. a 中国科学院藏药研究重点实验室 中国科学院西北高原生物研究所 西宁 810008;
    b 曲阜师范大学化学与化工学院 曲阜 273165
  • 收稿日期:2018-07-21 修回日期:2018-08-31 出版日期:2019-02-25 发布日期:2018-09-18
  • 通讯作者: 魏伟 E-mail:weiweiqfnu@163.com
  • 基金资助:

    青海省国际科技合作专项基金(Nos.2018-HZ-806,2017-HZ-806)、青海省藏药重点实验室(Nos.2017-ZJ-Y11)、山东省自然科学基金(Nos.ZR2018MB009,ZR2016JL012)、国家自然科学基金(Nos.21302109,21302110,21601106)资助项目.

Direct Synthesis Sulfonamides from Nitroarenes and Sulfonyl Chlorides in Water

Yue Huilana, Bao Penglib, Wang Leileib, Lü Xiaoxiab, Yang Daoshanb, Wang Huab, Wei Weia,b   

  1. a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Qinghai 810008;
    b School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165
  • Received:2018-07-21 Revised:2018-08-31 Online:2019-02-25 Published:2018-09-18
  • Contact: 10.6023/cjoc201807033 E-mail:weiweiqfnu@163.com
  • Supported by:

    Project supported by the International Cooperation Project of Qinghai Province (Nos. 2018-HZ-806, 2017-HZ-806), the Qinghai Key Laboratory of Tibetan Medicine Research (No. 2017-ZJ-Y11), the Natural Science Foundation of Shandong Province (Nos. ZR2018MB009, ZR2016JL012), and the National Natural Science Foundation of China (Nos. 21302109, 21302110, 21601106).

报道了一种简单实用的磺酰胺绿色合成方法,以硝基苯和磺酰氯为原料,铁粉为唯一还原剂,纯水作为溶剂.该反应具有反应成本低,溶剂环境友好,反应条件温和,底物适用性广的优点.

关键词: 水, 绿色有机合成, 磺酰胺, 磺酰氯, 铁粉

A simple and practical route for construction of various sulfonamides from nitroarenes and sulfonyl chlorides with iron powder as the sole reductant in water (green solvent) under open-air conditions was developed. The protocol features low-cost, environmentally benign solvent, mild reaction conditions and wide broad substrate scope.

Key words: water, green organic synthesis, sulfonamides, sulfonyl chlorides, iron power