有机化学 ›› 2019, Vol. 39 ›› Issue (1): 109-116.DOI: 10.6023/cjoc201808007 上一篇    下一篇

所属专题: 庆祝陈庆云院士九十华诞 有机氟化学合辑

综述与进展

三氟甲基三氮唑及四氮唑化合物的合成研究进展

张发光, 彭星, 马军安   

  1. 天津大学理学院化学系 天津市分子光电科学重点实验室 天津化学化工协同创新中心 天津 300072
  • 收稿日期:2018-08-07 修回日期:2018-09-14 发布日期:2018-10-12
  • 通讯作者: 张发光, 马军安 E-mail:zhangfg1987@tju.edu.cn;majun_an68@tju.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21472137,21532008,21772142)和国家重点基础研究发展计划(973计划,No.20014CB745100)资助项目.

Recent Advances in the Synthesis of CF3-Substituted Triazoles and Tetrazoles

Zhang Faguang, Peng Xing, Ma Jun'an   

  1. Tianjin Key Laboratory of Molecular Optoelectronic Sciences, and Tianjin Collaborative Innovation Center of Chemical Science & Engineering, Department of Chemistry, Tianjin University, Tianjin 300072
  • Received:2018-08-07 Revised:2018-09-14 Published:2018-10-12
  • Contact: 10.6023/cjoc201808007 E-mail:zhangfg1987@tju.edu.cn;majun_an68@tju.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21472137, 21532008, 21772142) and the National Basic Research Program of China (973 Program, No. 2014CB745100).

三氟甲基取代的三氮唑及四氮唑化合物在药物、农药、催化及材料等领域发挥着越来越重要的作用,其合成方法也日益受到重视.对近10年来三氟甲基三氮唑及四氮唑化合物的合成方法研究进展进行了分类归纳总结,着重展示了三氟甲基炔烃、三氟乙酰基衍生物、三氟甲基吡喃酮及三氟重氮乙烷等含氟砌块在这两类杂环合成中的应用.

关键词: 三氟甲基, 三氮唑, 四氮唑, 含氟杂环, 环加成反应

Trifluoromethylated triazoles and tetrazoles have emerged as increasingly important heterocycles in pharmaceuticals, agrochemicals, catalysis, and materials. As a consequence, great attention has been paid to the efficient synthesis of these valuable CF3-containing molecules. Herein, the advances in the past decade towards the synthesis of CF3-substituted triazoles and tetrazoles are summarized. The remarkable progress in the utilization of versatile CF3-functionalized building blocks including CF3-containing alkynes, CF3-containing carbonyl compounds, CF3-containing pyrones and trifluorodiazoethane (CF3CHN2) is demonstrated accordingly.

Key words: trifluoromethyl group, triazole, tetrazole, fluorine-containing heterocycle, cycloaddition