有机化学 ›› 2019, Vol. 39 ›› Issue (5): 1304-1315.DOI: 10.6023/cjoc201809034 上一篇    下一篇

综述与进展

咪唑并[1,2-a]吡啶化合物绿色合成的研究进展

赵鑫雨a, 丁扬扬a, 吕英涛b, 康从民a   

  1. a 青岛科技大学化工学院 青岛 266042;
    b 青岛科技大学海洋学院 青岛 266042
  • 收稿日期:2018-09-27 修回日期:2018-11-24 出版日期:2019-05-25 发布日期:2019-01-10
  • 通讯作者: 康从民 E-mail:qustndds@163.com
  • 基金资助:

    海洋生物活性物质和现代分析技术的关键实验室(No.MBSMAT-2017-06)资助项目.

Research Progress on Green Synthesis of Imidazo[1,2-a]pyridine Compounds

Zhao Xinyua, Ding Yangyanga, Lü Yingtaob, Kang Congmina   

  1. a College of Chemical Engineering, Qingdao University of Science and Technology, Shandong Province, Qingdao 266042;
    b Ocean College, Qingdao University of Science and Technology, Shandong Province, Qingdao 266042
  • Received:2018-09-27 Revised:2018-11-24 Online:2019-05-25 Published:2019-01-10
  • Contact: 10.6023/cjoc201809034 E-mail:qustndds@163.com
  • Supported by:

    Project supported by the Key Laboratory of Marine Bioactive Substance and Modern Analytical Technique (No. MBSMAT-2017-06).

咪唑并[1,2-a]吡啶化合物是由五元和六元稠和的氮杂环化合物,在多种天然产物中被发现,表现出广泛的药理学活性,具有重要的研究意义和广阔的医药应用前景,因此有关于此类化合物的多样性的合成策略被不断报道.近年来,绿色化学是当代化学的热门方向之一,科学家们对绿色合成越来越重视,不断开发出各种绿色合成方案,其中一锅“多组分”反应、微波反应和固相合成这几种绿色、高效的合成方法一直是研究热点,就从这三类绿色合成的方法对咪唑[1,2-a]吡啶类化合物近几年绿色合成的研究进展加以概括总结.

关键词: 绿色合成, 一锅"多组分反应", 微波反应, 固相合成

Imidazo[1,2-a]pyridine compounds were 5- and 6-membered nitrogen heterocyclic compounds, which were found in various natural products and exhibited a wide range of pharmacological activities, and were widely used in medical chemistry. Imidazo[1,2-a]pyridines have important research significance and broad medical application prospects, so the synthetic strategy literatures on the diversity of such compounds have been continuously reported. In recent years, green chemistry was one of the hot trends in contemporary chemistry. More and more attention is paid to green synthesis and constantly developing various green synthesis solutions. Among them, one-pot "multi-component" reaction, microwave reaction and solid phase synthesis, which were green and high-efficiency synthetic methods, have been the focus of research. From the three types of green synthesis methods, The research progress of imidazole[1,2-a]pyridine green synthesis in recent years is summarized.

Key words: green synthesis, one pot "multi-component reaction", microwave reaction, solid phase synthesis