N-磺基脒类化合物合成研究进展

doi:10.6023/cjoc202003019

摘要/Abstract

脒类化合物因其独特的偕二氮结构，在合成含氮化合物方面具有重要作用.作为脒类化合物中独特的一类，N-磺基脒类化合物更是多种重要有机合成反应的关键中间体，在现代有机合成中占有举足轻重的位置.基于这一背景，对N-磺基脒类化合物的合成进展进行了综述.依据反应特点，分别基于胺氧化酰化反应、炔-叠氮-胺三组分反应、烯胺碳-碳键官能化、酰胺活化以及其它相关的反应等方面的研究进展进行介绍，以期为相关领域的研究工作提供指导作用.

关键词: N-磺基脒, 合成, 胺氧化, 酰胺活化, 三组分, 烯胺反应

Due to the special gem-nitrogen structure, amidines are important compounds in the synthesis of nitrogen contaning products. As a class of featured amidines, the N-sulfonyl amidines are key intermediates in a number of pivatol organic syntheses, and thus ocuppy significant position in modern organic synthesis. In this context, the research advances on the synthesis of N-sulfonyl amidines are herein reviewed. Based on the key reaction features, the introduction covers the synthetic methods of enamination by tertiary enamine oxidation, amide activation, akyne-azide-amine three-component reaction, enamine carbon-carbon bond functionalization and other related reactions. It is expected that this review will provide guidelines for the reasearch work in related areas.

Key words: N-sulfonyl amidine, synthesis, amine oxidation, amide activation, three-component, enamine reaction

引用此文

郑茜茜, 刘云云, 万结平. N-磺基脒类化合物合成研究进展[J]. 有机化学, 2020, 40(7): 1891-1900.

Zheng Xixi, Liu Yunyun, Wan Jie-Ping. Advances in the Synthesis of N-Sulfonyl Amidines[J]. Chinese Journal of Organic Chemistry, 2020, 40(7): 1891-1900.

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