有机化学 ›› 2020, Vol. 40 ›› Issue (7): 1874-1890.DOI: 10.6023/cjoc201912031 上一篇    下一篇

综述与进展

胺和亚胺氮甲基化反应的研究进展

严沣a,b, 蔡爽a,b, 闻武a,b, 文蔚a,b, 李博解a, 汪连生a, 朱磊a,c   

  1. a 湖北工程学院化学与材料科学学院 湖北孝感 432000;
    b 湖北大学材料科学与工程学院 武汉 430062;
    c 华中科技大学生物无机化学与药物湖北省重点实验室 武汉 430074
  • 收稿日期:2019-12-22 修回日期:2020-04-05 发布日期:2020-04-17
  • 通讯作者: 李博解, 汪连生, 朱磊 E-mail:bojie.li@hbeu.edu.cn;wangls@hbeu.edu.cn;lei.zhu@hbeu.edu.cn
  • 基金资助:
    国家自然科学基金(No.21774029)、湖北省高等学校优秀中青年科技创新团队计划(No.T201816)、湖北省自然科学基金(No.2019CFB354)、生物无机化学与药物湖北省重点实验室开放基金(No.BCMM201805)、孝感市自然科学计划(No.XGKJ201910047)、湖北省“楚天学者”计划(朱磊)和湖北工程学院高水平硕士学位论文培育资助项目.

Recent Advances and Applications in N-Methylation of Amines and Imines

Yan Fenga,b, Cai Shuanga,b, Wen Wua,b, Wen Weia,b, Li Bojiea, Wang Lianshenga, Zhu Leia,c   

  1. a School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan, Hubei 432000;
    b School of Materials Science and Engineering, Hubei University, Wuhan 430062;
    c Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, Huazhong University of Science and Technology, Wuhan 430074
  • Received:2019-12-22 Revised:2020-04-05 Published:2020-04-17
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21774029), the Hubei University Excellent Young and Middle-Aged Science and Technology Innovation Team Project (No. T201816), the Opening Fund of Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica (No. BCMM201805), the Natural Science Foundation of Xiaogan City (No. XGKJ201910047), the "Chutian Scholar" Program of Hubei Province (Lei Zhu), and the High-Level Master's Thesis Cultivation Project of Hubei Engineering University.

胺类化合物的氮甲基化反应是一类重要的有机合成反应,在实验室研究与工业合成中具有重要的应用.传统的氮甲基化反应会涉及使用易燃易爆且剧毒的物质,而新兴的制备方案很好的解决了这方面的问题,更加符合绿色化学的标准和环境保护的需求.对于氮甲基化反应,C1碳源的选择直接决定了该反应的催化剂、反应条件、反应机理及底物范围等.将从不同碳源的角度介绍近年来胺和亚胺氮甲基化反应的研究进展,并对其作用机理进行相关阐述.

关键词: 氮甲基化, 二氧化碳, 甲酸, 甲醇, 金属催化剂

N-Methylation of amines and imines is one of the most important reactions for C-N bond formation. It is widely utilized for both laboratary research and industrial applications. Traditional methylation reactions involve the use of flammable, explosive and toxic starting materials. In contrast, newly developed methods have overcome this point and provide a mild strategy. In this transformation, C1 carbon source for the methyl group is important which determines the type of catalyst, reaction conditions and substrate scope. Herein, the research progress for the N-methylation of amines and imines is summarized based on different C1 carbon source.

Key words: N-methylation, carbon dioxide, formic acid, methanol, metal catalyst