有机化学 ›› 2003, Vol. 23 ›› Issue (10): 1091-1098. 上一篇    下一篇

研究论文

抗癌核苷类似物

吴耀文;蒋宇扬;付华;杨杰;赵玉芬   

  1. 清华大学
  • 出版日期:2003-10-25 发布日期:2003-10-25

Nucleoside Analogues as Anticancer Agents

Wu Yaowen;Jiang Yuyang;Fu Hua;Yang Jie;Zhao Yufen   

  1. Key Laboratory of Bioorganic Phosphorus Chemistry, of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University
  • Online:2003-10-25 Published:2003-10-25

综述了近年来核苷类抗癌药物的最新研究进展,分别介绍了具有抗癌活性的核 苷类似物的作用机制和药物代谢机理、各种核苷类似物抗癌剂的分类、次黄嘌呤核 苷酸脱氢酶(IMPDH)抑制剂以及核苷氨基磷酸酯前药的结构与抗癌活性关系。

关键词: 抗癌化疗剂, 核苷, 抑制剂, 氨基磷酸 P, 次黄嘌呤, 抗癌药, 药理

The recent progress of nucleoside analogues as anticancer agents is reviewed. The mechanisms for the action of these nucleoside analogues and drag metabolism are introduced. Especially the inosine 5'- monophosphate dehydrogenase (IMPDH) inhibitors are described. At last the relationship between the structure of nucleoside phosphoramidates and their anticancer activity is discussed.

Key words: nucleoside anticancer agent;NUCLEOSIDE;INHIBITOR;PHOSPHORAMIDIC ACID P, ACETOACETIC ACID P;ANTICARCINOGEN;PHARMACOLOGY;

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