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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (03): 282-289. 上一篇    下一篇

综述与进展

钯催化羰基衍生物α位的芳基化反应及其在天然产物合成中的应用

邵志会，张洪彬*   

  1. (云南大学药学院 昆明 650091)
  • 收稿日期:2004-02-25 修回日期:2004-07-15 发布日期:2005-02-28
  • 通讯作者: 张洪彬

Palladium-Catalyzed α-Arylation of Carbonyl Derivatives and Its Applications in the Synthesis of Natural Products

SHAO Zhi-Hui,ZHANG Hong-Bin*   

  1. (School of Pharmacy, Yunnan University, Kunming 650091
  • Received:2004-02-25 Revised:2004-07-15 Published:2005-02-28
  • Contact: ZHANG Hong-Bin

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对钯催化羰基衍生物α位的芳基化反应的研究进展做了论述, 重点介绍了酮羰基化合物α-芳基化反应、酰胺类化合物α-芳基化反应和酯类化合物α-芳基化反应的研究进展. 此外, 对钯催化酮α-芳基化反应在γ-Lycorane合成中的应用和钯催化酰胺α-芳基化反应在Cherylline, Latifine及Physovenine等天然产物合成中的应用也进行了专门介绍.

关键词: 酰胺, 酯, 应用, 天然产物, 合成, α-芳基化, 钯催化, 酮

The progress in palladium-catalyzed α-arylation of carbonyl derivatives is reviewed with emphasis on α-arylation of ketones, amides and esters. The applications of α-arylation of ketones in the synthesis of γ-Lycorane as well as α-arylation of amides in the synthesis of natural products including cherylline, latifine and physovenine are also described.

Key words: ester, application, natural product, ketone, syn-thesis, α-arylation, amide, palladium-catalyzed