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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (03): 272-281. 上一篇    下一篇

综述与进展

氮-氧偶极化合物在不对称催化反应研究中的应用

申永存*,1，李燕霞2，闻雪敬2，冯小明3   

  1. (1 武汉理工大学化工学院 武汉 430070)
    (2 湖北省新型反应器与绿色化学工艺重点实验室 武汉 430074)
    (3 四川大学化学学院 成都 610064)
  • 收稿日期:2004-03-22 修回日期:2004-07-07 发布日期:2005-02-28
  • 通讯作者: 申永存

Application of N-Oxides in Asymmetric Catalytic Reactions

SHEN Yong-Cun*,1,LI Yan-Xia2,WEN Xue-Jing2,FENG Xiao-Ming3   

  1. (1 Faculty of Chemical Engineering, Wuhan University of Technology, Wuhan 430070)
    (2 Hebei Key Laboratory of Novel Chemical Reactor and Green Technology, Wuhan 430074)
    (3 Faculty of Chemistry, Sichuan University, Chengdu 610064)
  • Received:2004-03-22 Revised:2004-07-07 Published:2005-02-28
  • Contact: SHEN Yong-Cun

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1906

被引次数

10

氮-氧偶极化合物中的氮-氧偶极具有较强的极性, 表现出良好的亲电、亲核性能, 可与许多物质形成分子加成产物, 也可与许多金属离子和可提供空轨道的非金属原子形成配合物和发生配位作用. 近年来已发现, 手性和非手性的氮-氧偶极化合物可用于一些不对称催化反应中, 着重讨论这方面的进展状况.

关键词: 氮-氧偶极化合物, 不对称催化, 反应, 应用

N-O moiety of N-oxide has high polarity and shows excellent nucleophilicity and electrophilicity. It can form addition products with many substances, complex and coordinate with many metal ions and non-metal atoms with empty orbital. More recently, chiral and achiral N-oxides have been found to catalyze some asymmetric reactions, such as Sakurai-Hosomi, Aldol, Strecker ones as well as ring opening of epoxides and cyanosilylation of ketones. The paper was focused on the development of application of N-oxides in asymmetric catalytic reactions.

Key words: asymmetric catalysis, reaction, application, N-oxide