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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (10): 1418-1423. 上一篇    下一篇

研究简报

2-取代苯基-5-(3,4,5-三甲氧基苯基)-1,3,4-噁二唑衍生物的合成及生物活性研究

陈江，许瑞卿，宋宝安*，金林红
胡德禹，杨松，张国平   

  1. (贵州大学精细化工研究开发中心 教育部绿色农药和农业生物工程重点实验室 贵阳 550025)
  • 收稿日期:2006-01-17 修回日期:2006-03-20 发布日期:2006-09-19
  • 通讯作者: 宋宝安

Synthesis and Bioactivity of 2-Substitued Phenyl-5-(3,4,5-trimethoxy- phenyl)-1,3,4-oxadiazole Derivatives

CHEN Jiang,XU Rui-Qing,SONG Bao-An*,JIN Lin-Hong
HU De-Yu,YANG Song,ZHANG Guo-Ping   

  1. (Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Research and Development
    Center for Fine Chemicals, Guizhou University, Guiyang 550025)
  • Received:2006-01-17 Revised:2006-03-20 Published:2006-09-19
  • Contact: SONG Bao-An

PDF

1238

被引次数

35

合成了10个2-取代苯基-5-(3,4,5-三甲氧基苯基)-1,3,4-噁二唑衍生物. 并经过元素分析, IR, 1H NMR, 13C NMR对其结构进行了确认. 初步生物活性测试表明, 部分化合物具有一定抗癌活性.

关键词: 1,3,4-噁二唑衍生物, 合成, 抗癌活性

Ten 2-substitued phenyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazoles were synthesized and characterized by elemental analysis, IR, 1H NMR and 13C NMR spectra. Bioassay of the title compounds indicated that some of them exhibited weak to moderate antitumor activity.

Key words: synthesis, antitumor activity, 1,3,4-oxadiazole derivative