有机化学 ›› 2014, Vol. 34 ›› Issue (6): 1074-1091.DOI: 10.6023/cjoc201312034 上一篇    下一篇

综述与进展

环境友好型Michael加成的研究进展

李志峰a, 侯海亮a, 应安国b, 许松林a   

  1. a. 天津大学化工学院 天津 300072;
    b. 台州学院医药化工学院 台州 318000
  • 收稿日期:2013-12-30 修回日期:2014-01-26 出版日期:2014-06-25 发布日期:2014-02-14
  • 通讯作者: 应安国, 许松林 E-mail:yinganguo@163.com;slxu@tju.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 21106090,21176170)资助项目.

Research Progress in the Environmentally-Friendly Michael Addition

Li Zhifenga, Hou Hailianga, Ying Anguob, Xu Songlina   

  1. a. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072;
    b. School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000
  • Received:2013-12-30 Revised:2014-01-26 Online:2014-06-25 Published:2014-02-14
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21106090, 21176170).

Michael加成反应是有机合成领域一类非常重要的反应. 随着人们环保意识的增强和对绿色化学研究的深入,环境友好型Michael加成取得了诸多成功. 综述了近5年来离子液体、酶催化、负载固相催化、聚乙二醇(PEG)等参与的Michael加成反应的研究进展. 着重分析了反应体系的高效性、催化剂可能的催化反应机理以及催化剂的循环使用性,并以此对环境友好型Michael加成的发展做出了展望.

关键词: Michael加成, 环境友好, 催化, 绿色化学

Michael addition is one kind of important reaction in the organic field. With the enhancement of environmental awareness and the depth of green chemistry research, environmentally-friendly Michael addition has made many successes. The research progress over the past 5 years in the Michael addition involving ionic liquids, enzyme catalysis, solid phase supported catalysis and polyethylene glycol (PEG) is reviewed. This paper is consisted of six parts, focusing on the efficiency of the reaction system, the probable catalytic mechanism and the recycle of the catalyst. In the first part, a brief introduction is given. Then the Michael addition used the ionic liquid as catalyst or/and solvent is elaborated. In this part, acidic ionic liquid, basic ionic liquids and chiral ionic liquid are described, respectively. As a mild catalyst, enzymes are described in the third part. The solid phase supported catalysis has been used in many reaction without exception to Michael addition. So, in the fourth part, the catalysts of polymer supported, silica-supported and superparamagnetic nano supported are stated. Following, the successful use of polyethylene glycol (PEG) as a green solvent is presented. Finally, the conclusion, the existing problems of these green technologies and the prospect are summarized.

Key words: Michael addition, environmentally-friendly, catalysis, green chemistry