有机化学 ›› 2014, Vol. 34 ›› Issue (9): 1845-1850.DOI: 10.6023/cjoc201403022 上一篇    下一篇

研究论文

铜催化一锅法合成吡咯[1,2-a]喹喔啉衍生物

蒋增强, 张杰, 童耀, 史雪松, 苗大状, 韩世清   

  1. 南京工业大学生物与制药工程学院, 南京 211816
  • 收稿日期:2014-03-10 修回日期:2014-04-17 出版日期:2014-09-25 发布日期:2014-05-06
  • 通讯作者: 韩世清 E-mail:hanshiqing@njut.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21072095)和江苏省研究生创新工程(No. CXLX13_433)资助项目.

One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives through Copper-Catalyzed Cascade Reactions

Jiang Zengqiang, Zhang Jie, Tong Yao, Shi Xuesong, Miao Dazhuang, Han Shiqing   

  1. College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816
  • Received:2014-03-10 Revised:2014-04-17 Online:2014-09-25 Published:2014-05-06
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21072095), the Graduate Student Innovation Project in Jiangsu Province (No. CXLX13_433).

建立了一种简单实用、经济高效的以邻碘苯胺、吡咯甲醛为起始原料,廉价的CuI为催化剂,价廉、易获得的2,2-联吡啶为配体,110 ℃条件下一锅法合成吡咯[1,2-a]喹喔啉类衍生物的催化体系,得到中等到优良产率. 本方法具有催化剂廉价易得、操作简便、合成效率高的优点.

关键词: 一锅法合成, 吡咯[1,2-a]喹喔啉, 铜催化

A simple, efficient, inexpensive one-pot method for the pyrrolo[1,2-a]quinoxaline derivatives synthesized from 2-formylazoles and o-aminoiodoarenes was developed by using cheap CuI as catalyst, inexpensive and readily available 2,2'-bipyridine as ligand at 110 ℃. The reaction provides an efficient protocol to a series of pyrrolo[1,2-a]quinoxaline derivatives in good to high yields, and benefits of readily available catalyst and synthesis of high efficiency.

Key words: one-pot synthesis, pyrrolo[1,2-a]quinoxalines, copper-catalyst