有机化学 ›› 2014, Vol. 34 ›› Issue (8): 1487-1498.DOI: 10.6023/cjoc201405011 上一篇    下一篇

综述与进展

过渡金属催化的双齿导向基辅助的惰性C(sp3)—H键芳基化

张博, 管晗曦, 刘斌, 史炳锋   

  1. 浙江大学化学系 杭州 310007
  • 收稿日期:2014-05-07 修回日期:2014-05-30 出版日期:2014-08-25 发布日期:2014-06-11
  • 通讯作者: 史炳锋 E-mail:bfshi@zju.edu.cn
  • 基金资助:
    国家自然科学基金(No.J1210042)和中央高效基本科研业务费(No.2014QNA3008)资助项目.

Transition-Metal-Catalyzed Arylation of Unactivated C(sp3)—H Bonds Assisted by Bidentate Directing Groups

Zhang Bo, Guan Hanxi, Liu Bin, Shi Bingfeng   

  1. Department of Chemistry, Zhejiang university, Hangzhou 310007
  • Received:2014-05-07 Revised:2014-05-30 Online:2014-08-25 Published:2014-06-11
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. J1210042) and the Fundamental Research Funds for the Central Universities (No. 2014QNA3008).

近年来,过渡金属催化的惰性碳氢键官能团化受到广泛关注,然而,C(sp3)—H键由于低极性、高解离能和低选择性,其选择性活化尤为困难. 综述了过渡金属催化的双齿导向基辅助的C(sp3)—H键芳基化的最新研究进展,主要探讨了不同过渡金属催化下芳基化反应的底物范围、反应机理和合成应用.

关键词: 过渡金属, 双齿导向基, C(sp3)—H键活化, 芳基化

Recently, transition-metal-catalyzed C—H functionalization has attracted tremendous interest as a valuable tool for carbon-carbon and carbon-heteroatom bond formation. However, due to the inertness of C(sp3)—H bonds and the difficulty to achieving high selectivity among the many chemically similar entities in a given molecule, the selective activation of C(sp3)—H bonds remains a great challenge. The recent progress in transition-metal-catalyzed arylation of unactivated C(sp3)—H bonds assisted by bidentate directing groups is reviewed, including the scope of reactions, mechanism and synthetic applications.

Key words: transition-metal, bidentate directing group, C(sp3)—H activation, arylation