有机化学 ›› 2015, Vol. 35 ›› Issue (1): 1-14.DOI: 10.6023/cjoc201409019 上一篇    下一篇

综述与进展

铜催化的α,β-不饱和化合物的不对称共轭硼化反应研究进展

刘强a,b, 田兵a,b, 田平b, 童晓峰a, 林国强b   

  1. a 华东理工大学上海市功能性材料化学重点实验室 上海 200237;
    b 中国科学院上海有机化学研究所天然产物有机合成化学重点实验室 上海 200032
  • 收稿日期:2014-09-09 修回日期:2014-09-30 出版日期:2015-01-25 发布日期:2014-10-09
  • 通讯作者: 田平, 童晓峰, 林国强 E-mail:tianping@sioc.ac.cn;tongxf@ecust.edu.cn;lingq@sioc.ac.cn
  • 基金资助:

    国家自然科学基金(Nos. 21372243, 21102161)资助项目.

Recent Progress on Cu-Catalyzed Asymmetric Conjugate Borylation to α,β-Unsaturated Compounds

Liu Qianga,b, Tian Binga,b, Tian Pingb, Tong Xiaofenga, Lin Guo-Qiangb   

  1. a Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237;
    b CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2014-09-09 Revised:2014-09-30 Online:2015-01-25 Published:2014-10-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21372243, 21102161).

有机硼化合物是一种重要的有机合成中间体, 有机硼酸及其衍生物可以被很容易的转化为一系列的功能性化合物并保持其空间构型不变. 铜催化的α,β-不饱和化合物和联硼酸酯的不对称加成反应已经成为一个新颖的合成手性有机硼化合物的方法. 综述了铜催化的α,β-不饱和化合物的不对称共轭硼化研究进展, 其中包括了双膦配体、卡宾配体以及其它配体诱导的共轭硼化反应.

关键词: 铜, α,β-不饱和化合物, 不对称共轭硼化

Organoborons are an important class of organic compounds, because organoboronic acids and their derivatives can be readily converted into a wide variety of functionalities in a stereospecific manner. Cu-catalyzed asymmetric conjugate borylation of unsaturated compounds with bis(pinacolato)diboron (B2pin2) has emerged as a novel synthetic tool to afford a variety of organoboron compounds. Herein, this research progress, which involves using bisphosphine, N-heterocyclic carbine, and other chiral ligands, is summarized.

Key words: copper, α,β-unsaturated compounds, asymmetric conjugate borylation