有机化学 ›› 2019, Vol. 39 ›› Issue (8): 2251-2256.DOI: 10.6023/cjoc201904017 上一篇    下一篇

所属专题: 陈茹玉先生诞辰100周年

研究论文

三丁基膦催化的查尔酮与丙烯酸酯的交叉Rauhut-Currier反应

谷迎春a,b, 黄有a   

  1. a 南开大学化学学院元素有机化学研究所 元素有机化学国家重点实验室 天津 300071;
    b 天津城建大学理学院 天津 300384
  • 收稿日期:2019-04-08 修回日期:2019-05-04 出版日期:2019-08-25 发布日期:2019-05-15
  • 通讯作者: 黄有 E-mail:hyou@nankai.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21672109,21871148,21472097)和天津市自然科学基金(No.15JCYBJC20000)资助项目.

Tributylphosphine Catalyzed Cross Rauhut-Currier Reaction of Chalcones and Acrylates

Gu Yingchuna,b, Huang Youa   

  1. a State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071;
    b School of Science, Tianjin Chengjian University, Tianjin 300384
  • Received:2019-04-08 Revised:2019-05-04 Online:2019-08-25 Published:2019-05-15
  • Contact: 10.6023/cjoc201904017 E-mail:hyou@nankai.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21672109, 21871148, 21472097) and the Natural Science Foundation of Tianjin City (No. 15JCYBJC20000).

Rauhut-Currier反应是一种高效构筑碳碳键的原子经济性的方法,但较差的选择性一直限制了该反应的应用,经过条件筛选,以三丁基膦为催化剂,成功实现了查尔酮与丙烯酸酯之间的交叉Rauhut-Currier反应,可以有效合成多官能团化丙烯酸酯类化合物.

关键词: 三丁基膦, 催化, Rauhut-Currier反应, 查尔酮, 丙烯酸酯

Rauhut-Currier (RC) reaction is an effective atom-economic method to construct C-C bond. However, the application of this reaction is limited by the lack of selectivity. Herein, an efficient intermolecular cross Rauhut-Currier reaction between chalcones and acrylates in the presence of the tributylphosphine catalyst was developed, the reactions were carried out in mild conditions, and performed well with a series of substrates, delivering the desired products with acceptable to good yields.

Key words: tributylphosphine, catalysis, Rauhut-Currier reaction, chalcone, acrylate