Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (03): 483-491.DOI: 10.6023/cjoc201209034 Previous Articles     Next Articles


抗肿瘤生物碱Lamellarin N和Lamellarin L的研究进展

王爱玲a,d, 赵壮志a,b, 郑学仿b,c, 曹洪玉b,c   

  1. a 大连大学环境与化学工程学院 大连 116622;
    b 大连大学辽宁省生物有机化学重点实验室 大连 116622;
    c 大连大学生物工程学院 大连 116622;
    d 东北农业大学农学院 哈尔滨 150030
  • 收稿日期:2012-09-24 修回日期:2012-10-16 发布日期:2012-10-26
  • 通讯作者: 郑学仿
  • 基金资助:

    国家自然科学基金(No. 20871024)、辽宁省优秀人才培养计划(No. RC-04-10)、大连市优秀青年科技人才基金(No. 2009J22DW038)资助项目.

Recent Research Progress in Anticancer Alkaloid Lamellarin N and Lamellarin L

Wang Ailinga,d, Zhao Zhuangzhia,b, Zheng Xuefangb,c, Cao Hongyub,c   

  1. a College of Environment and Chemical Engineering, Dalian University, Dalian 116622;
    b Liaoning Key Laboratory of Bio-organic Chemistry, Dalian University, Dalian 116622;
    c College of Bioengineering, Dalian University, Dalian 116622;
    d College of Agronomy, Northeast Agricultural University, Harbin 150030
  • Received:2012-09-24 Revised:2012-10-16 Published:2012-10-26
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20871024), the Talents Training Plan of Liaoning Province (No. RC-04-10) and the Outstanding Young Talent Fund from the Dalian Science and Technology Bureau (No. 2009J22DW038).

Lamellarins, a family of hexacyclic pyrrole alkaloids, originally isolated from marine invertebrates, display promising activities. The lamellarin N (LMN) is a member of the lamenllarin compounds. LMN exhibits a significant cytotoxicity against a large panel of cancer cell lines and potent inhibitors of various protein kinases which is better than lamellarin D (LMD). LMN and lamellarin L (LML) are similar in structure and activity. Therefore, the isolation, synthesis, biological activity and anti-cancer activity mechanism of LMN and LML are summarized.

Key words: lamellarin N, lamellarin L, protein kinases inhibitor, cytotoxic activity, chemical synthesis