Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (10): 2220-2225.DOI: 10.6023/cjoc201304037 Previous Articles     Next Articles

5-胺基-2-氧代-7-芳基-2,3,4,7-四氢-1,3-噻唑并[4,5-b]吡啶-6-甲酰胺类化合物的微波合成

孙宏顺a,b, 王建强a, 郭成a, 沈临江a   

  1. a 南京工业大学理学院 南京 211816;
    b 南京化工职业技术学院化学工程系 南京 210048
  • 收稿日期:2013-04-23 修回日期:2013-05-28 出版日期:2013-10-25 发布日期:2013-07-03
  • 通讯作者: 郭成, 沈临江 E-mail:guocheng@njut.edu.cn; ljshen@njut.edu.cn
  • 基金资助:

    国家自然科学青年基金(No. 21106069)、南京化工职业技术学院院级重点(No. NHKY-2013-2)资助项目

Synthesis of 5-Amino-2-oxo-7-aryl-2,3,4,7-tetrahydro-1,3-thiazolo[4,5-b]pyridine-6-carboxamide Derivatives under Microwave Irradiation

Sun Hongshuna,b, Wang Jianqianga, Guo Chenga, Shen Linjianga   

  1. a Nanjing University of Technology, Nanjing 211816;
    b Nanjing College of Chemical Technology, Nanjing 210048
  • Received:2013-04-23 Revised:2013-05-28 Online:2013-10-25 Published:2013-07-03
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21106069) and the Key Program of Nanjing College of Chemical Technology (No. NHKY-2013-2).

Five new 5-amino-2-oxo-7-aryl-2,3,4,7-tetrahydro-1,3-thiazolo[4,5-b]pyridine-6-carboxamide derivatives, which are different with the products of 5-amino-2-oxo-7-aryl-2,3,4,7-tetrahydro-1,3-thiazolo[4,5-b]pyridine-6-carbonitrile derivatives in the conventional heating conditions, were synthesized by using arylmethylene malononitrile, 2,4-thiazolidinedione and ammonium acetate in one-pot via microwave irradiation techniques. And the reaction mechanism was discussed. The structures of these compounds were characterized by 1H NMR, IR, MS and elemental analysis.

Key words: 2,4-thiazolidinedione, thiazolo[4,5-b]pyrirnidine, microwave irradiation, synthesis