Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (10): 2244-2258.DOI: 10.6023/cjoc201305035 Previous Articles     Next Articles

Report

近年活性维生素D类似物的合成进展概况

蔡祖恽   

  1. 上海闵行航北路180弄55号601室 上海 201105
  • 收稿日期:2013-05-22 修回日期:2013-06-18 出版日期:2013-10-25 发布日期:2013-07-03
  • 通讯作者: 蔡祖恽 E-mail:zuyun_cai@yahoo.com

Recent Progress in the Syntheses of Active Vitamin D Analogues

Cai Zuyun   

  1. Hang Bei Road, Lane 180, No. 55, Room 601, Shanghai, 201105
  • Received:2013-05-22 Revised:2013-06-18 Online:2013-10-25 Published:2013-07-03

Based on 1α,25-dihydroxyvitamin D3 exhibits its critical role in regulating calcium and phosphorus homeostasis, also regulates cell growth, differentiation, antiproliferation, apoptosis, and immunomodulation. This review concisely describes some of the current frontiers of vitamin D research in the design and syntheses of the analogs of C2-substituted-, 19-nor-, C2-substituted-19-nor-1α,25-dihydroxyvitamin D3 (125D), C22-oxa-125D, Gemini vitamin D analogs, VDR-antago-nists (Vitamin D receptor), des-C,D-19-nor-125D and the relation between the conformations and the biological activities.

Key words: 1α,25-dihydroxyvitamin D3, vitamin D analogues, des-C,D-125D analogs, VDR-antagonist, synthesis, biological activities