Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (1): 1-25.DOI: 10.6023/cjoc201308018 Previous Articles     Next Articles



黄阳阳, 王梦嘉, 厍梦尧, 杨征, 刘萍, 李剑利, 史真   

  1. 西北大学化学与材料科学学院 合成与天然功能分子化学教育部重点实验室 西安 710069
  • 收稿日期:2013-08-14 修回日期:2013-09-10 发布日期:2013-09-25
  • 通讯作者: 李剑利
  • 基金资助:

    国家自然科学基金(Nos. 21272184,20972124,J1210057);陕西省自然科学基础研究计划项目基金(No. 2012JQ2007);陕西省教育厅专项计划项目基金(No. 12JK0584);西北大学研究生创新基金(No. YZZ12030);国家大学生创新性计划项目基金(No. 201210697011)资助项目.

Recent Progress in the Fluorescent Probe Based on Spiro Ring Opening of Xanthenes and Related Derivatives

Huang Yangyang, Wang Mengjia, She Mengyao, Yang Zheng, Liu Ping, Li Jianli, Shi Zhen   

  1. Key Laboratory of Synthetic and Natural Functional Molecular Chemistry, Ministry of Education, College of Chemistry & Material Science, Northwest University, Xi'an 710069
  • Received:2013-08-14 Revised:2013-09-10 Published:2013-09-25
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21272184, 20972124, J1210057), the Shaanxi Provincial Natural Science Fund Project (No. 2012JQ2007), the Special Science Research Foundation of Education Committee in Shaanxi Province (No. 12JK0584), the Northwest University Science Foundation for Postgraduate Students (No. YZZ12030), and the Chinese National Innovation Experiment Program for University Students (No. 201210697011).

Fluorescent probe technology has specially outstanding function in the track of the heterogeneous recognition behaviors and the information from the internal status of the complicated biological and environmental systems. The spiral ring structure of xanthene and related derivatives which substrate triggered fluorescent switching is the most extensively used model in construction of novel photosensitive fluorescent probes. In recent years, design, synthesis and functional regulation and control of this type of probe are active sub-discipline with continuous breakthroughs. In this paper, the most recent advances in the detection of different metal cations, pH deviations, anions which based on xanthene and related derivatives are reviewed. The construction of xanthene based fluorescent probes, the recognition mechanisms and the application in bioimaging and environmental monitoring are particularly highlighted.

Key words: xanthenes, fluorescent probe, bioimaging