Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (1): 94-111.DOI: 10.6023/cjoc202206044 Previous Articles     Next Articles



马延慧, 武宇乾, 王晓旭, 高贵*(), 周欣*()   

  1. 河北农业大学理工学院 河北沧州 061100
  • 收稿日期:2022-06-23 修回日期:2022-07-01 发布日期:2022-09-08
  • 通讯作者: 高贵, 周欣
  • 基金资助:

Research Progress of Near-Infrared Fluorescent Probes Based on 1,3-Dichloro-7-hydroxy-9,9-dimethyl-2(9H)-acridone (DDAO)

Yanhui Ma, Yuqian Wu, Xiaoxu Wang, Gui Gao(), Xin Zhou()   

  1. College of Science and Technology, Hebei Agricultural University, Cangzhou, Hebei 061100
  • Received:2022-06-23 Revised:2022-07-01 Published:2022-09-08
  • Contact: Gui Gao, Xin Zhou
  • Supported by:
    Graduate Student Innovation Ability Training Project of Hebei Province(CXZZSS2022101)

1,3-Dichloro-7-hydroxy-9,9-dimethyl-2(9H)-acridone (DDAO) is an excellent near-infrared fluorescent dye with near-infrared emission, low pKa (≈5.0), high water solubility and high quantum yield (Φ=0.39), which has attracted much attention in recent years in the field of fluorescent probes. The researches prove that the fluorescent probes designed and synthesized based on this dye can work in mild aqueous solutions, and have excellent sensing performance, such as rapid reaction, high selectivity and sensitivity, low detection limit and obvious colorimetric signal change. In addition, the low cytotoxicity of this class of probes is of significant application for the detection of living cells and organisms. The research progress of fluorescent probes based on DDAO and its derivatives, mainly including the molecular design, action mechanism and application of probes in the recognition and detection of biological enzymes, reactive oxygen species, reactive nitrogen species, proteins and Pd0, is reviewed, and the development prospect of this type of fluorescent probes is prospected.

Key words: 1,3-dichloro-7-hydroxy-9,9-dimethyl-2(9H)-acridone (DDAO), fluorescent probe, near infrared, detection