Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (8): 1692-1698.DOI: 10.6023/cjoc201402034 Previous Articles     Next Articles



韩小强, 万川, 杨冬燕, 杜士杰, 袁小勇, 肖玉梅, 覃兆海   

  1. 中国农业大学理学院应化系 北京 100193
  • 收稿日期:2014-02-27 修回日期:2014-03-24 发布日期:2014-04-10
  • 通讯作者: 覃兆海
  • 基金资助:

Synthesis and Plant Growth Regulating Activities of iso-Abscisic Acid

Han Xiaoqiang, Wan Chuan, Yang Dongyan, Du Shijie, Yuan Xiaoyong, Xiao Yumei, Qin Zhaohai   

  1. Department of Applied Chemistry, China Agricultural University, Beijing 100193
  • Received:2014-02-27 Revised:2014-03-24 Published:2014-04-10
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 20972184) and the National Hi-Tech Research and Development Program of China (No. 2011AA10A206).

The iso-abscisic acid (iso-ABA) analogs 11, 12, 13 and 14 were synthesized via regioselective addition of acetylides to enediones, selective reduction, Dess-Martin oxidation and Lindgren oxidation. The racemic mixtures 11 were resolved by chiral HPLC. These iso-ABA analogs and ABA were tested for their inhibitory activity in four bioassays. (+)-iso-ABA 11 exhibited high ABA-like activity, including the ability to effectively inhibit seed germination and seedling growth. The analogs 12, 13, 14 were also prepared and biological activities were investigated. Comparison of four bioassays, the iso-abscisic acid analogs had better activity in lettuce seed germination.

Key words: phytohormone, iso-abscisic acid analogs, synthesis, biological activities