Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (8): 1499-1508.DOI: 10.6023/cjoc201403015 Previous Articles     Next Articles



冯亚栋, 张红, 程国林, 崔秀灵   

  1. 分子药物教育部工程研究中心 厦门市海洋与基因工程药物重点实验室 华侨大学分子药物学研究所 厦门 361021
  • 收稿日期:2014-03-06 修回日期:2014-05-04 发布日期:2014-05-23
  • 通讯作者: 程国林,崔秀灵;
  • 基金资助:


Synthesis of Indole Derivatives via Domino Reactions

Feng Yadong, Zhang Hong, Cheng Guolin, Cui Xiuling   

  1. Engineering Research Center of Molecular Medicine, Ministry of Education, Xiamen Key Laboratory of Marine and Gene Drugs, Institutes of Molecular Medicine, Huaqiao University, Xiamen 361021
  • Received:2014-03-06 Revised:2014-05-04 Published:2014-05-23
  • Supported by:

    Project supported by the Minjiang Scholar Program (No. 10BS216), the Xiamen Southern Oceanographic Center (No. 13GYY003NF16), and the Fundamental Research Funds of Huaqiao University

Domino reactions have received great attentions of organic chemist as an efficient protocol to synthesize indole derivatives. In this process, it is not required isolating or purifying the intermediates, changing the reaction condition and adding reagents. Transition metal-catalyzed domino reactions to synthesize indole derivatives have already been widely studied and become a powerful tool. In this paper, the progress of recent domino reactions applied to construct indole and its derivatives is reviewed, focusing on the transition metal-catalyzed domino reactions, and detailed analysis on the versatility and applications.

Key words: domino reactions, metal catalysis, indole derivatives, synthesis