Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (9): 1889-1894.DOI: 10.6023/cjoc201403051 Previous Articles     Next Articles


孙宏滨a, 孙源华a, 陈文龙b, 秦鹏a, 齐轩a   

  1. a 东北大学理学院, 沈阳 110819;
    b 攀钢集团研究院有限公司, 钒钛资源综合利用国家重点实验室, 攀枝花 617000
  • 收稿日期:2014-03-25 修回日期:2014-04-25 发布日期:2014-05-07
  • 通讯作者: 孙宏滨, 齐轩
  • 基金资助:

    国家自然科学基金(No. 21003018)资助项目.

An Efficient Approach to the Synthesis of 5-Aryl-1H-tetrazole Derivatives Accompanying with the Cleavage of Ester Group

Sun Hongbina, Sun Yuanhuaa, Chen Wenlongb, Qin Penga, Qi Xuana   

  1. a Department of Chemistry, Northeastern University, Shenyang 110819;
    b Pangang Group ResearchInstitude Co., Ltd., State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization, Panzhihua 617000
  • Received:2014-03-25 Revised:2014-04-25 Published:2014-05-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21003018).

5-Phenyl-1H-tetrazoles were synthesized by catalytic [3+2] cycloaddition with aryl nitriles and sodium azide. Indium trichloride was used as an efficient catalyst. The tetrazoles binding with varieties of functional groups were synthesized in good to quantitative yields. This tetrazole synthetic protocol also showed remarkable de-carboxylation activity. Esters were cleaved to carboxylic acids or alcohols in one pot.

Key words: indium trichloride, catalysis, tetrazole, synthesis, [3+2] cycloaddition, cleavage of ester