Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (1): 70-84.DOI: 10.6023/cjoc201408038 Previous Articles     Next Articles



梅青刚a,b, 袁伟成a, 王淳b   

  1. a 中国科学院成都有机化学研究所 成都 610041;
    b 中国科学院成都生物研究所 成都 610041
  • 收稿日期:2014-08-29 修回日期:2014-09-12 发布日期:2014-09-16
  • 通讯作者: 王淳
  • 基金资助:

    国家自然科学基金(No. 21172214)资助项目.

Progress in the Synthesis of 3-Hydroxyflavones

Mei Qingganga,b, Yuan Weichenga, Wang Chunb   

  1. a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041;
    b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041
  • Received:2014-08-29 Revised:2014-09-12 Published:2014-09-16
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21172214).

Flavonols, also known as 3-hydroxyflavones, are a kind of unique flavonoids that widely distributed in the plant kingdom, and have been associated with a wide variety of biological activities and pharmaceutical applications. Four principal synthetic approaches to flavonol skeleton including Auwers synthesis, Algar-Flynn-Oyamada reaction (AFO), Baker-Venkataraman synthesis and flavone oxidation by 3,3-dimethyldioxirane (DMDO) are summarized. The regioselective methylation, prenylation and glycosylation of polyhydroxyl flavonols are presented as well.

Key words: flavonol, synthesis, AFO reaction, derivatization, regioselectivity