Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 570-577.DOI: 10.6023/cjoc201412048 Previous Articles     Next Articles



王明明a, 王子潇b, 商明a, 戴辉雄a   

  1. a 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032;
    b 上海大学化学系 上海大学创新药物研究中心 上海 200444
  • 收稿日期:2014-12-29 修回日期:2015-01-26 发布日期:2015-01-28
  • 通讯作者: 戴辉雄
  • 基金资助:

    国家自然科学基金(No. 21472211)资助项目.

Transition-Metal-Catalyzed C—H Alkynylation

Wang Mingminga, Wang Zixiaob, Shang Minga, Dai Huixionga   

  1. a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    b Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444
  • Received:2014-12-29 Revised:2015-01-26 Published:2015-01-28
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21472211).

Alkynyl compounds are paramount skeletons in pharmaceuticals and natural products, and great importance has been attached to its synthesis by organic chemists. Recently, transition-metal-catalyzed C—H alkynylation has attracted tremendous interest as a valuable tool for construction of alkynyl compounds. This review gives a summary of progress having been made in the field of the C(sp2)—H and C(sp3)—H alkynylation over the last ten years.

Key words: alkynylation, C—H activation, alkyne, cross dehydrogen coupling