Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (7): 1451-1468.DOI: 10.6023/cjoc201501027 Previous Articles     Next Articles



彭宇然a,b, 孙亦诚a, 王德才a, 韦萍b, 欧阳平凯b, 周国春a   

  1. a 南京工业大学药学院 南京 211816;
    b 南京工业大学生物与制药工程学院 南京 211816
  • 收稿日期:2015-01-21 修回日期:2015-03-05 发布日期:2015-03-09
  • 通讯作者: 王德才
  • 基金资助:

    国家自然科学基金(No. 30973621)资助项目.

Recent Progress in Synthesis of Andrographolide Derivatives with Anti-tumor Activities

Peng Yurana,b, Sun Yichenga, Wang Decaia, Wei Pingb, Ouyang Pingkaib, Zhou Guochuna   

  1. a College of Pharmaceutical Sciences, Nangjing Tech University, Nanjing 211816;
    b College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816
  • Received:2015-01-21 Revised:2015-03-05 Published:2015-03-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 30973621).

As one of the major active constituents in Andrographis panniculata (Burm. f.) Nees of Acanthaceae family, andrographolide is proved to possess a wide range of biological activities. In recent years, numerous studies show that the structural modification of andrographolide could enhance its anti-tumor activities. Therefore, according to the structural properties of andrographolide derivatives, five types of derivatives classified by different basic skeletons are denoted as the skeleton of andrographolide derivatives, the skeleton of 14-deoxyandrographolide derivatives, the skeleton of dehydroandrographolide derivatives, the skeleton of isoandrographolide derivatives and the skeleton of 12-ring replaced andrographolide derivatives. On this basis, the synthesis and anti-tumor activities of andrographolide derivatives are reviewed, and the structure activity relationship are also summarized preliminarily. The future trends of the derivatives research are discussed in the end.

Key words: andrographolide, derivatives, synthesis, anti-tumor