Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1999-2003.DOI: 10.6023/cjoc201503026 Previous Articles     Next Articles



李正义, 石嵩, 庄跃, 郑崇谦, 张金龙, 孙小强   

  1. 常州大学石油化工学院 江苏省绿色催化材料与技术重点实验室 常州 213164
  • 收稿日期:2015-03-18 修回日期:2015-04-16 发布日期:2015-05-14
  • 通讯作者: 孙小强
  • 基金资助:

    国家自然科学基金(No. 21002009)、江苏省高校自然科学研究(Nos. 12KJA150002, 14KJA150002)、江苏省科技(BY2014037-01)和江苏省青蓝工程资助项目.

Improvement of the Synthesis of Isothiocyanates

Li Zhengyi, Shi Song, Zhuang Yue, Zheng Chongqian, Zhang Jinlong, Sun Xiaoqiang   

  1. Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164
  • Received:2015-03-18 Revised:2015-04-16 Published:2015-05-14
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21002009), the Major Program for the Natural Science Research of Jiangsu Colleges and Universities (Nos. 12KJA150002, 14KJA150002), the Scientific and Technological Project of Jiangsu Province (BY2014037-01), and the Qing Lan Project of Jiangsu Province.

Isothiocyanates were prepared from the reactions of phenyl chlorothionoformate and various primary amines vis one-step or two-step process without additional base. The one-step process is good at highly active amines, while two-step approach is suitable for all kinds of amines. This method has many merits such as environment-friendly, easily available raw materials, low toxicity and convenient operation, which has a good application prospect in industry.

Key words: isothiocyanate, phenyl chlorothionoformate, primary amine, synthesis