Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1805-1819.DOI: 10.6023/cjoc201504040 Previous Articles     Next Articles



李日东, 王元强, 葛泽梅, 李润涛   

  1. 北京大学药学院 天然药物及仿生药物国家重点实验室 北京 100191
  • 收稿日期:2015-04-27 修回日期:2015-05-22 发布日期:2015-06-04
  • 通讯作者: 李润涛
  • 基金资助:

    国家自然科学基金(Nos. 21172011, 21372019)资助项目.

Progress in the Studies on Synthesis and Biological Properties of Dithiocarbamates

Li Ridong, Wang Yuanqiang, Ge Zemei, Li Runtao   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191
  • Received:2015-04-27 Revised:2015-05-22 Published:2015-06-04
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172011, 21372019).

Due to the diverse biological activities of dithiocarbamates, their researches of synthesis and pharmacological activity have been attracting considerable interest in the areas of organic chemistry and medicinal chemistry. In the aspect of synthetic methods, this review is focused on the progress in the synthesis of dithiocarbamates under the following conditions: strong alkali, weak alkali, using water or ionic liquids as solvent and solvent-free conditions. In the aspect of biological activities, This review is focused on the progress in the following activities of dithiocarbamates: the treatment of chronic alcoholism, antioxidant, antiviral, antibacterial, cholinesterase inhibition, cancer prevention and antitumor activities.

Key words: dithiocarbamates, synthesis, biological activity, progress