Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (2): 283-296.DOI: 10.6023/cjoc201507001 Previous Articles     Next Articles



饶红红a, 权正军b, 白林a, 叶鹤琳a   

  1. a 兰州城市学院化学与环境科学院学院 兰州 730070;
    b 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2015-07-01 修回日期:2015-09-14 发布日期:2015-10-13
  • 通讯作者: 饶红红
  • 基金资助:

    国家自然科学基金(Nos. 21265009, 21362032)资助项目.

Progress on the Synthesis of Enantiomerically Pure 3,4-Dihydropyrimidin-2-one Derivatives

Rao Honghonga, Quan Zhengjunb, Bai Lina, Ye Helina   

  1. a School of Chemistry and Environmental Science, Lanzhou City University, Lanzhou 730070;
    b College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2015-07-01 Revised:2015-09-14 Published:2015-10-13
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21265009, 21362032).

3,4-Dihydropyrimidinethiones are chiral molecules, however, only racemic products are isolated in the most reported Biginelli reactions. It has been proved that the absolute configuration of the C(4) stereogenic center has significant influence on the biological activity. The development in the accessing of optically active 3,4-dihydropyrimidinethiones focusing on the recent advances in the asymmetric catalytic Biginelli reactions is summarized.

Key words: enantiomerically pure 3,4-dihydropyrimidin-2-(1H)-ones, asymmetric catalysis, Biginelli reaction, multicomponent reactions