Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (2): 377-383.DOI: 10.6023/cjoc201510020 Previous Articles     Next Articles



戴红a,c, 陈佳a, 曹雄飞b, 苗文科c, 石玉军a,b, 方建新c, 叶林玉a, 仲苏林b   

  1. a 南通大学化学化工学院 南通 226019;
    b 联合国南通农药剂型开发中心 南通 226006;
    c 南开大学元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2015-10-19 修回日期:2015-11-05 发布日期:2015-11-20
  • 通讯作者: 石玉军, 仲苏林;
  • 基金资助:

    国家自然科学基金(Nos. 21202089, 21372135)和南通市科技计划(Nos. AS2013004, MS22015020, AS2014011)资助项目

Synthesis and Bioactivity of Novel Pyridine Phenyl Ethers Bearing N-heterocycles

Dai Honga,c, Chen Jiaa, Cao Xiongfeib, Miao Wenkec, Shi Yujuna,b, Fang Jianxinc, Ye Linyua, Zhong Sulinb   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b United Nations Nantong Pesticide Forulation Development Centre, Nantong 226006;
    c State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071
  • Received:2015-10-19 Revised:2015-11-05 Published:2015-11-20
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), and the Science and Technology Project Fund of Nantong City (Nos. AS2013002, MS22015020, AS2014011).

In order to find novel pyridine phenyl ether lead compounds, a series of novel pyridine phenyl ether derivatives containing N-heterocycles were prepared by the strategy of active substructure combination. Their structures were determined by 1H NMR, 13C NMR, IR and elemental analysis. Preliminary bioassay data displayed that some of the designed compounds exhibited good insecticidal activity. Additionally, some target compounds showed significant anti-tumor activities.

Key words: N-heterocycle, pyridine phenyl ether, synthesis, bioactivity