Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (5): 1060-1064.DOI: 10.6023/cjoc201510031 Previous Articles     Next Articles



贾婉a, 赵立志b, 魏恒旭b, 朱林东b, 傅磊a, 陈蔚春b   

  1. a. 上海交通大学药学院 上海 200240;
    b. 葛兰素史克上海医药研发有限公司 上海 201203
  • 收稿日期:2015-10-26 修回日期:2015-12-16 发布日期:2016-01-04
  • 通讯作者: 陈蔚春
  • 基金资助:


Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent

Jia Wana, Zhao Lizhib, Wei Hengxub, Zhu Lindongb, Fu Leia, Chen Weichunb   

  1. a. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240;
    b. Research and Developemnt Center in Shanghai of GlaxoSmithKline, Shanghai 201203
  • Received:2015-10-26 Revised:2015-12-16 Published:2016-01-04
  • Supported by:

    Project supported by the Union-Education Program of Shanghai Jiao Tong University and the Research and Development Center of GlaxoSmithKline.

A green, practical and efficient iron-catalyzed, base free cross-coupling reaction of non-activated secondary alkyl halides with the alkynes Grignard reagent has been developed to afford a variety of alkyl alkynes in high yields, using iron(III) chlorides as catalyst. This approach is quick and easy to operate. It exhibits promising in industry since utilizing the low-cost iron as a catalyst instead of expensive palladium or nickel.

Key words: iron-catalyzed, secondary alkyl choloride, alkynes Grignard reagents, cross-coupling reactions, green chemistry