Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1241-1265.DOI: 10.6023/cjoc201511004 Previous Articles     Next Articles



张钊瑞, 郑晓霖, 郭长彬   

  1. 首都师范大学化学系北京 100048
  • 收稿日期:2015-11-03 修回日期:2016-01-07 发布日期:2016-02-01
  • 通讯作者: 郭长彬
  • 基金资助:


Application of Ugi/De-Boc/Cyclization Strategy in the Synthesis of Nitrogen-Containing Heterocycles

Zhang Zhaorui, Zheng Xiaolin, Guo Changbin   

  1. Department of Chemistry, Capital Normal University, Beijing 100048
  • Received:2015-11-03 Revised:2016-01-07 Published:2016-02-01
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 30873140), the Program for Excellent Talents of Beijing City (No. 20071D0501600227) and the Beijing Municipal Commission of Education (No. KM201010028011).

Ugi/de-Boc/cyclization (UDC) strategy represents a “three-step, one-pot procedure”, employing the Ugi multi-component reaction utilizing one bi-functional group substrates with N-Boc-protected amino, followed by Boc-deprotection and cyclization to synthesize nitrogen-containing heterocycles. This strategy has the characteristics of rapid, efficiency, economy and structural diversity, which can be used to build libraries of complex nitrogen-containing heterocycles and has drawn much attention recently. In this paper, the research progress of UDC strategy in the synthesis of five-, six- and seven-mem- bered heterocycles and natural products were summarized.

Key words: UDC, Ugi reaction, de-Boc group, cyclization, nitrogen-containing heterocycle, synthesis, multi-component reaction