Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (7): 1539-1554.DOI: 10.6023/cjoc201511038 Previous Articles     Next Articles


次氯酸荧光探针的研究进展 2017-2018 Awarded

王延宝a,b, 赵宝祥b   

  1. a. 济宁学院化学与化工系 曲阜 273155;
    b. 山东大学化学与化工学院 济南 250100
  • 收稿日期:2015-11-19 修回日期:2016-03-07 发布日期:2016-03-18
  • 通讯作者: 赵宝祥

Recent Progress in Fluorescent Probes for the Detection of Hypochlorous Acid

Wang Yanbaoa,b, Zhao Baoxiangb   

  1. a. Department of Chemistry and Chemical Engineering, Jining University, Qufu 273155;
    b. School of Chemistry and Chemical Engineering, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100
  • Received:2015-11-19 Revised:2016-03-07 Published:2016-03-18

Hypochlorous acid (HClO) is one of the biologically important reactive oxygen species (ROS), which plays important roles in the human immune defence system, and contributes to the destruction of invading bacteria and pathogens. But excessive formation of HClO can lead to tissue damage and a series of human diseases, such as atherosclerosis, arthritis and even cancers, etc. Therefore, a rapid, sensitive, and selective detection of HClO in biological samples is important. In recent years, fluorescent probes for HClO have been developed due to various advantages such as simplicity of operation, lower limit of detection, low toxicity, high sensitivity and selectivity. A general overview of the recent research on the design, synthesis and application of fluorescent probes for hypochlorous acid is provided.

Key words: hypochlorous acid, fluorescent probe, reactive oxygen species, bioimaging