Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1431-1437.DOI: 10.6023/cjoc201512019 Previous Articles     Next Articles



石玉军a,b, 李阳a, 方源a, 叶林玉b, 陈佳b, 戴红b   

  1. a 江苏科技大学环境与化学工程学院镇江 212003;
    b 南通大学化学化工学院南通 226019
  • 收稿日期:2015-12-14 修回日期:2016-01-07 发布日期:2016-02-02
  • 通讯作者: 石玉军, 戴红;
  • 基金资助:


Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety

Shi Yujuna,b, Li Yanga, Fang Yuana, Ye Linyub, Chen Jiab, Dai Hongb   

  1. aSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003;
    b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
  • Received:2015-12-14 Revised:2016-01-07 Published:2016-02-02
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (Nos. 2011-SWYY-009, 2013-SWYY-013), and the Science and Technology Project Fund of Nantong City (Nos. AS2014011, CP12013002).

In order to find novel cyanoacrylate lead compounds, 17 new cyanoacrylate compounds bearing fluoride methyl pyrazole moiety were synthesized by the method of active substructure combination. They were structurally confirmed by 1H NMR, 13C NMR and elemental analysis. The structures of compounds 7b, 7f, 7j and 7o were also tested through MS technique. Preliminary bioassay data showed that some of the target compounds displayed important anti-tumor activities.

Key words: fluoride methyl pyrazole, cyanoacrylate, synthesis, biological activity